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ObjectiveTo explore the mental health status and relevant factors among community residents during the normalization stage of prevention and control of COVID-19. MethodsFrom August 28 to September 7， 2020， an online cross-sectional survey using snowball sampling was conducted among community residents via Wenjuanxing platform， and their mental health status were assessed using Patients' Health Questionnaire Depression Scale-9 item（PHQ-9）， Generalized Anxiety Disorder-7 item（GAD-7）， Insomnia Severity Index（ISI） and Chinese Perceived Stress Scale（CPSS）. ResultsAmong the 476 community residents， the detection rates of depression， anxiety， insomnia and high perceived stress were 32.35%， 21.22%， 24.58% and 48.74%， respectively. In terms of gender， the detection rate of high perceived stress was higher in male than in female（χ2=5.269）； in terms of marital status， the detection rates of depression and anxiety among the unmarried， divorced or widowed residents was higher than those of the married residents（χ2=5.251， 8.851）； in terms of mental health service status， the detection rates of depression， anxiety， insomnia and high perceived stress among residents with mental health service needs was higher than those among residents without the needs（χ2=46.316， 66.934， 20.153， 21.576）， with statistical significance（P<0.05 or 0.01）. Correlation analysis showed that the age of community residents was negatively correlated with CPSS score（r=-0.171， P<0.01）， sleep duration was negatively correlated with PHQ-9， GAD-7 and ISI scores（r=-0.210， -0.247， -0.297， P<0.01）， and time spent following news on COVID-19 per day was negatively correlated with ISI score（r=-0.097， P<0.05）. ConclusionDuring the normalization stage of prevention and control of COVID-19， the majority of community residents experience the symptoms of depression， anxiety， insomnia and high perceived stress. Male and younger residents are more likely to experience high levels of perceived stress. Those with shorter sleep duration and needs for mental health services are more likely to experience symptoms of depression， anxiety and insomnia， and those with short time spent following news on COVID-19 are more likely to experience insomnia symptom.
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Objective:To explore the feature of impaired sustaind attention in the stable patients with bipolar disorder and their first degree relatives.Methods:Totally 76 patients with bipolar disorder meeting with, 83 first degree relatives of patients and 81 healthy controls, were employed and evaluated with continuous performance test (CPT).Results:In reaction time task (a simple performance), all of CPT parameters were higher in patients group than in the first degree relatives group and controlled group (Ps＜0.01), while all of CPT parameters in the first degree relatives group were similar to those in healthy controls (Ps＞0.05).In X task (a complex performance), the results of CPT in the first degree relatives group were between the patients and the normal controls, and the differences were statistically significant (Ps＜0.05).Conclusion:The sustained attention function may have a certain hereditary apparent in stable patients with bipolar disorder.
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Objective To explore the correlation between the methylation level of 5-hydroxytryptamine receptor 1A(HTR1A) gene promoter region and severity of symptom in the manic epi-sode patients with bipolar disorder type Ⅰ(BD-Ⅰ). Methods Fifty six manic episode patients with BD-Ⅰand fifty nine healthy controls were randomly included in the study. The level of HTR1A gene promoter meth-ylation was measured with pyrosequencing technique in both manic episode patients with BD-Ⅰ and the healthy controls. The severity of symptoms was assessed with score of Bech-Rafaelsen Mania Rating Scale (BRMS) in patients with BD-Ⅰ. Pearson correlation analysis was employed to explore the correlation be-tween the serum level of HTR1A promoter methylation and score of BRMS in BD-Ⅰgroup. Results In-creased serum level of HTR1A gene promoter methylation was found in manic episode patients with BD-Ⅰ((66. 55±10. 55)%) compared with that in healthy controls((54. 03±8. 85)%)(P<0. 01). Positive corre-lation was found between the serum level of HTR1A gene promoter methylation and total score of BRMS in manic patient with BD-Ⅰ(r=0. 534,P<0. 01). Conclusion The current findings suggest that the serum level of HTR1A gene promoter methylation can be an epigenetic indicator for severity of manic symptom in BD-Ⅰ.
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Objective To explore the relationship between aggressive behavior with thyroid hormone or cortisol and in schizophrenic patients. Methods According to the past violence history and modified overt aggression scale( MOAS) weighted total scores,108 schizophrenic patients were divided into aggressive group ( n=69) and non-aggressive group( n=39) . Positive and Negative Syndrome Scale ( PANSS) total scores, serum thyroid hormone levels and cortisol concentration were compared between the two groups before and af-ter 2,4 weeks treatment. And correlations of PANSS and sub-scales scores,thyroid hormone levels and corti-sol concentration with MOAS weighted total scores and subscales scores were analyzed before these patients receiving treatment. Results Before treatment,total scores of PANSS,positive symptoms and general psy-chopathology scores in aggressive group((94.19±12.71),(23.77±4.94),(52.61±6.45))were higher than that in non-aggressive group ((83.26±11.21),(21.36±7.10),(45.49±6.84)) and these differences were significant(P0. 05 ) . Free thyroxine ( FT4 ) level of aggressive group ( ( 14. 41 ± 3. 58 ) pmol/L) was higher than that of non-aggressive group ((12.95±2.66)pmol/L) before treatment and the difference was significant(P0.05) . After 2 or 4 weeks treatment,the differences between the two groups in TSH,FT3,FT4,TT3,TT4 levels were not significant(P>0.05). The differences between the two groups of cortisol concentration were not significant before and after 2,4 weeks treatment(P>0.05) . MOAS weighted to-tal scores were positively correlated with PANSS total scores,negative symptoms scores,general psychopathol-ogy scores and level of FT4,and their r values were 0.471,0.204,0.531,0.239(all P<0.05). Verbal aggres-sion was positively correlated with PANSS total scores,positive symptoms scores and general psychopathology scores,and their r values were 0.213,0.215,0.292(P<0.05). Auto-aggression was positively correlated with PANSS total scores and general psychopathology scores,and their r values were 0.278,0.382(P<0.05) . Psy-chical aggression was positively correlated with PANSS total scores,negative symptoms scores,general psy-chopathology scores and level of FT4,and their r values were 0.361,0.193,0.338,0.276(P<0.05). Conclusion The total scores of PANSS,positive symptoms,general psychopathology scores,level of FT4 and their variances can reflect severity of aggression and predict aggressive behavior in schizophrenic patients. Concen-tration of cortisol is not associated with aggressive behavior and can not be used as a predictor of aggressive behavior in schizophrenic patients.
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Objective: To examine the correlation between paliperidone plasma concentration and clinical efficacy in the patients with schizophrenia. Methods:Totally 50 schizophrenia patients were treated by paliperidone. The plasma concentration of paliperidone was monitored by RP-HPLC at the weekend of the 2 nd, 4 th and 6 th week, the clinical efficacy was evaluated using the positive and negative syndrome scale ( PANSS) , and the correlation between paliperidone plasma concentration and clinical efficacy was analyzed. Results:The mean plasma concentration of paliperidone was (31. 89 ± 17. 36) ng·ml-1 at the weekend of the 6th week, and no cor-relation was found between paliperidone plasma concentration and the clinical efficacy (r=0. 146,P=0. 074). Paliperidone plasma concentration in 12 patients with adverse drug reactions (ADR) was higher than that in the patients without ADR [(45. 87 ± 19. 21)ng ·ml-1 vs (27. 06 ± 11. 13) ng·ml-1, P <0. 01]. Conclusion: Paliperidone plasma concentration shows significant individual differences. With the increase of paliperidone plasma concentration, clinical efficacy isn't necessarily improved, while the incidence of ADR may be increased. Therefore, the monitoring of paliperidone plasma concentration is recommended to optimize the therapeutic reg-imen.