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OBJECTIVE:To observe the effects of butylphthalide combined with alteplase on neural funetion and cognitive function and serological indexes as homocysteine(Hcy)in patients with acute cerebral infarction(ACI).METHODS:Clinical information of 78 ACI patients in emergency department of our hospital during Feb.2140-Apr.2017 were analyzed and then divided into control group and observation group according to therapy plan,with 39 cases in each group. Both groups received conventional treatment and Aspirin enteric-coated tablets orally. Control group was given Alteplase for injection 0.9 mg/kg for verous thromblysis on the basis of conventional treatment. Observation group was additionally given Butyphthalide soft capsules 0.2 g orally,tid,on the basis of control group. Both groups were treated for consecutive 28 days. The clinical efficacies of 2 groups were observed. NIHSS and MMSE scores before treatment,3,7,14 and 28 d after treatment,the levels of Hcy,NSE and 6-k-PGF1a were observed in 2 groups;the occurrence of ADR was recorded. RESULTS:After treatment,total response rate of observation group was 92.31%,which was significantly higher than 71.79% of control group,with statistical significance(P<0.05). 3-28 d after treatment,NIHSS scores of 2 groups were decreased gradually and significantly lower than before treatment;MMSE scores of 2 groups were increased gradually and significantly higher than before treatment,with statistical significance(P<0.05 or P<0.01). 7-28 d after treatment,NIHSS score of observation group was significantly lower than that of control group at same time,while MMSE score was significantly higher than control group, with statistical significance(P<0.05 or P<0.01). After treatment,serum levels of Hcy and NSE in 2 groups were decreased significantly,and observation group was significantly lower than control group;the level of 6-k-PGF1a was increased significantly,and observation group was significantly higher than control group,with statistical significance(P<0.05 or P<0.01). There was no statistical significantce in the total incidence of ADR between 2 groups(P>0.05). CONCLUSIONS:Butylphthalide combined with alteplase can significantly improve neurologic impairment and cognitive function of ACI patients,reduce serum levels of Hcy and NSE and increase the level of 6-k-PGF1a. Clinical efficacy of it is significantly better than alteplase alone.
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ObjectiveTo investigate the clinical efficacy of hydroxyethyl starch 130/0.4 and sodium chloride injection in the treatment of patients with early hemorrhagic shock (HS).MethodsFifty-two cases of early HS were divided into compound sodium chloride injection group(control group,26 cases) and hydroxyethyl starch 130/0.4 sodium chloride injection group (treatment group,26 cases) by random digits table.The clinical effect,mean arterial pressure (MAP),respiratory rate (RR) and heart rate (HR) and serum sodium,serum chloride and prothrombin time(PT) were statistically analyzed before and after treatment for 60 min.ResultsCure rates in treatment group and control group were 84.6％ (22/26) and 38.5％ (10/26),and mortality rates were 15.4％ (4/26) and 61.5％ (16/26),respectively.The difference showed statistical significant(P ＜0.05).MAP,HR and RR in treatment group were obviously improved compared with control group[ (91.5 ± 8.6 )mm Hg( 1 mm Hg =0.133 kPa) vs.(78.5 ± 7.9 )mm H8,( 81.5 ±8.6) times/min vs.( 108.4 ± 10.2) times/min,(21.4 ± 5.3) times/min vs.(25.5 ± 4.6) times/min,P ＜ 0.05 ].Compared with control group,serum sodium,serum chloride and PT in treatment group were no significant difference(P ＞0.05).ConclusionHydroxyethyl starch 130/0.4 and sodium chloride injection could increase the effective circulating blood volume,and improve tissue and organ perfusion and reduce mortality during the patients with early HS.
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Objective To compare the efficacy of total pelvic floor reconstruction with mesh patch and vaginal hysterectomy with anterior and posterior vaginal wall repair for presby-pelvic floor dysfunction patients.Methods We randomly chose 92 pelvic floor dysfunction inpatients of our hospital from September 2007 to February 2009 and divided them into 2 groups:total pelvic floor reconstruction group(n=70) underwent total pelvic floor reconstruction with mesh patch[12 patients of this group complicated with stress incontinence,4 patients received tension free vaginal tape-obturator(TVT-O) simultaneously];control group(n=22) received vaginal hysterectomy with anterior and posterior vaginal wall repair(3 patients of this group complicated with stress incontinence).A follow-up for 3 to 18 months after the surgery were taken in all the patients.Results In total pelvic floor reconstruction group,no recidivate case was found and the FOP scores and cure rate were 0 and 100% respectively.In control group,there were 7 recidivate cases,all of who were primary vagina anterior wall bulge patients.The cure rate of control group was 68%;For the patients complicated with stress incontinence,they were all cured by TVT-0 or by ascending the front patch in total pelvic floor reconstruction group,but 1 case was as before operation and 2 cases were even worse in control group.Conclusion Total pelvic floor reconstruction with vicarious materials had a definite efficacy for presby-pelvic floor dysfunction.