ABSTRACT
Background: Kidney damage can occur due to exposure to nephrotoxic drugs, chemicals, Toxins and infections agents, ultimately leading to real failure, management of which is a Great challenge, So efforts have been focused on traditional and herbal medicines for the Treatment of real failure, Ashwagandha (withania somnifera) may have free radical Scavenging activity and can be used for the precention and treatment of kidney damage. Objective: To observe the histological ecidence of nephroprotective effect of Ashwagandha root against induced nephrotoxicity in rats . Materials and Methods: this study was done in the department of Physiology, Sir Salimullah Medical College, Dhaka A total number of 31 male Wistar albino rats were acclimatized for 14 days, then, these were divided into two groups, control group consisted of 18rats (Group A) and Ashwagandha pretreated and gentamicin-treated group consisted of 13 rats (Group B). Control group was again subdivided into baseline control and gentamicin-control groups (A1 and A2)-each And all the animals received basal diet for 22 consecutive days. In addition to this, animals of Group A2 teceived gentamicin subcutaneously (100 mg /kg body weight/day) from 15Th to 22 day and animals of Group B received Ashwagandha root extract (500mg / kg body weight/day )From 15TH to 22ND day All the animals were sacrificed on 23RD day. Then kidney samples were collected and histology was by using standard laboratory procedure. Results: Histological examination of kidney revealed abnormal histological findings in 100% of gentamicin-treated rats. But 92.31% of rats in Asruture and 7.69% showed mild histological changes. Conclusion: Ashwagandha root may have some nephroprotective effect against gentamichin induced nephorotoxicity