ABSTRACT
Abstract: Background: An oral condition associated to psoriasis is benign migratory glossitis. The review of the literature does not show any publication about heritability in both soriasis and benign migratory glossitis and prevalence of psoriasis in the Brazilian population. Objective: This research was carried out in order to determine the prevalence of psoriasis and benign migratory glossitis in the Brazilian population from a Brazilian sample, as well as the heritability in these conditions. Methods: Six thousand patients were studied from the records of the outpatient dermatology department. The sample had 129 patients with cutaneous psoriasis, 399 with benign migratory glossitis without psoriasis and a control group with 5,472 patients. After data collection, the statistical analysis was made using Woolf, Chi-square and Falconer tests. Results: The prevalence of psoriasis was 2.15% and the benign migratory glossitis was 7.0%. The prevalence of benign migratory glossitis in the psoriasis group was high (16.3%), and that was statistically significant. Family history in the psoriasis group was 38% for the condition itself and 2,75% for benign migratory glossitis and in the benign migratory glossitis group was 17.54% for the condition itself and 1.5% for psoriasis. The study of heritability was 38.8% for psoriasis and 36.6% for benign migratory glossitis, both with medium heritability. Study limitations: This study was only in the state of São Paulo. Conclusion: This is the first publication that quantifies how much of these conditions have a genetic background and how important the environmental factors are in triggering them.
Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Young Adult , Psoriasis/genetics , Psoriasis/epidemiology , Glossitis, Benign Migratory/genetics , Glossitis, Benign Migratory/epidemiology , Brazil/epidemiology , Prevalence , Retrospective Studies , Risk Factors , Sex DistributionABSTRACT
Os componentes das distribuiçöes dos níveis séricos de IgA, IgG e IgM foram investigados em uma amostra de cerca de 300 pessoas, habitantes de uma regiäo brasileira onde a doença de Chagas é endêmica. As distribuiçöes de IgG e IgM parecem ser compostas de 2 componentes, ambos assimétricos; a distribuiçäo de IgA é composta de apenas um componente. Estes resultados sugerem a açäo de um gene principal ou de um evento ambiental discreto sobre as distribuiçöes de IgG e IgM. Por sua vez, a distribuiçäo de IgA seria determinada por componentes multifatoriais