ABSTRACT
Abstract In Portugal, tetrahydrobiopterin (BH4)-responsive patients with phenylketonuria (PKU) are identified using a loading test (LT). Phenylalanine/natural protein (Phe/NP) intake is increased to elevate blood Phe prior to the LT. In a longitudinal retrospective study, the impact of Phe/NP titration post-LT in 58 patients (19.6 + 8.2 years) with PKU during 4 study periods (SPs) was examined. In SP1 (2010-2013), patients were diet treated only; in SP2 (2014), the Phe/NP titration was followed by the LT in SP3 (2015). In SP4 (2016), patients received diet treatment only (n » 49) or BH4 þdiet (n » 9). The median percentage blood Phe within the target range was higher in SP1 versus SP4 (64 [28-85] vs 45 [0-66]; P < .001). Our results suggest that transient Phe/NP titration, associated with a deliberate increase in NP, may adversely affect metabolic control. Controlled studies are necessary to examine the longer term impact of temporary increased NP with BH4 LT in non-BH4-responsive patients.
ABSTRACT
Este trabalho apresenta uma discussão sobre uma sessão sociopsicodramática fundamentada nos conceitos de espontaneidade/criatividade. Trata-se de um recorte de um trabalho realizado em uma Unidade Básica de Saúde da cidade de São Paulo, em que a autora investiga como a Metodologia Socionômica pode atuar na perspectiva de saúde da terceira idade e, em consequência, potencializar ações espontâneas, bem como facilitar a criação e o fortalecimento de vínculos nessa faixa etária.
This article presents and discusses a sociopsychodrama session based on the concepts of spontaneity/creativity. The study refers to part of a work that took place in a Basic Health Unit in São Paulo, in which the author aims at investigating how the Socionomic Methodology can work on healthcare for older people, and, as a result, enhance spontaneous actions and facilitate the development and strengthening of bonds in this age group.
Este artículo presenta y discute una sesión sociopsicodramática fundamentada en los conceptos de espontaneidad/creatividad. Se trata de un artículo de un trabajo realizado en una unidad básica de salud, en São Paulo, en el que la autora investiga como la Metodología Socionómica puede actuar con una perspectiva de salud para la tercera edad y, en consecuencia, potencializar acciones espontáneas, así como facilitar la creación y el fortalecimiento de vínculos en ese grupo etario.