ABSTRACT
Introducción. Debido a la fuerte industrialización de la Ciudad de Buenos Aires y alrededores, la población podría estar expuesta a metales. Para poder evaluar el nivel de exposición de los niños al cromo y al mercurio, es fundamental tener valores de referencia (VR) propios. El objetivo fue determinar los VR pediátricos para cromo y mercurio en la muestra aislada de orina. Población y métodos: Se incluyeron niños y niñas no expuestos a los contaminantes evaluados que concurrieron al Servicio de Bajo Riesgo y al Consultorio del Jardín Maternal del Hospital de Pediatría S.A.M.I.C. "Prof. Dr. Juan P. Garrahan". Se cuantificó cromo (UCr), mercurio (UHg) y creatinina urinarios. Se calcularon los p95 con su intervalo de confianza del 95 % [IC 95 %] según el concepto para VR de la German Human Biomonitoring Commission. Resultados: Se incluyeron 160 pacientes en el estudio. Se obtuvieron 144 muestras de niños y niñas de entre 1 y 17 años (mediana: 7 años). Se cuantificó UCr a 137 muestras y UHg a 129. La mediana y rango de cromo fue 0,54 (indetectable -3,06) µg/g de creatinina y la de mercurio fue 0,49 (indetectable -7,57) µg/g de creatinina.Conclusiones: Los VR fueron, para UCr, hasta 1,5 µg/l [1,2-2,8] y hasta 2,2 µg/g de creatinina [1,8-3,0] y para UHg, hasta 2,5 µg/l [1,8-4,8] y 3,2 µg/g de creatinina [2,5-4,7
Introduction. Due to the heavy industrialization of the Autonomous City of Buenos Aires and Greater Buenos Aires, the population may have become exposed to metals.To assess the level of exposure to chromium and mercury in children, it is critical to have local reference values (RVs). Our objective was to determine pediatric RVs for chromium and mercury in a single urine sample.Population and methods: Children who were not exposed to the studied contaminants and who attended the Department of Low Risk Conditions and the Daycare Center Office of Hospital de Pediatría S.A.M.I.C. "Prof. Dr. Juan P. Garrahan" were included. Urinary chromium (UCr), urinary mercury (UHg), and urinary creatinine were measured. The p95 and its corresponding 95 % confidence interval (CI) were estimated based on the RV concept proposed by the German Human Biomonitoring Commission.Results: The study included 160 patients. A total of 144 samples from children aged 1-17 years (median: 7 years) were collected. UCr was measured in 137 samples and UHg, in 129 samples. The median value of chromium was 0.54 µg/g of creatinine (range, undetectable to 3.06), while that of mercury was 0.49 µg/g of creatinine (range, undetectable to 7.57). Conclusions: The RVs for UCr were up to 1.5 µg/L [1.2-2.8] and up to 2.2 µg/g of creatinine [1.8-3.0], and for UHg, up to 2.5 µg/L [1.8-4.8] and 3.2 µg/g of creatinine [2.5-4.7]
Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Reference Values , Chromium/urine , Mercury/urine , Urban Population , Urine , Environmental Exposure/analysisABSTRACT
BACKGROUND: Lower gastrointestinal bleeding is usually self-limiting in about 80 of cases; however, surgical treatment may be required in selected cases. Preoperative precise identification of the bleeding source is crucial for a successful outcome. OBJECTIVE: To determine the most frequent diagnoses, as well as short and long-term results in a series of patients who underwent a surgical procedure for lower gastrointestinal bleeding. MATERIAL AND METHODS: Retrospective analysis of 39 patients operated upon for lower gastrointestinal bleeding from 1979 through 1997 in a referral center. Demographic data, history, physical examination, laboratory tests, resuscitative measures, preoperative work-up for identification of bleeding source, definitive cause of bleeding, surgical procedure, operative morbidity and mortality, as well as long-term status and recurrence of bleeding were recorded. RESULTS: There were 54 women and 46 men. Mean age was 56 years (range, 15-92). Most patients presented hematochezia (69). Colonoscopy was the most used diagnostic procedure (69). The bleeding source was located in 90 of patients. Diverticular disease was the most frequent cause of bleeding. A segmental bowel resection was the treatment in 97 of cases. Morbidity was 23 with 18 of mortality. Recurrence occurred in 9 of survivors. CONCLUSIONS: Morbidity and mortality were high. Patients who require a surgical operation should be carefully selected and evaluated with a complete work-up to determine the site and cause of bleeding.
Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Gastrointestinal Hemorrhage , Colonic Diseases/surgery , Recurrence , Colostomy , Cross-Sectional Studies , Retrospective Studies , Colonoscopy , Colectomy , Diverticulitis , Academies and Institutes , Gastrointestinal Hemorrhage , Mexico , Anastomosis, Surgical , Postoperative Complications/epidemiology , Colonic Diseases/diagnosis , Colonic Diseases/epidemiology , Colonic Diseases/etiologyABSTRACT
Se evaluaron 22 pacientes diabéticos con infecciones en miembros inferiores; 66,66% presentaron lesiones ulcerativas. La mayoría (90.9%). Mostró descompensación metábolica al ingreso, con algún grado de detonemia en el 54,55%. Todos presentaron alteración radiológica. La neuropatía periferica fue la patología asociada, más frecuente. En la evaluación microbiológica aeróbica se demostraron cultivos polimicrobianos en una alta proporción, siendo los gérmenes más encontrados: Staphilococcus aureus, Klebsiella pneumoniae. Pseadomona aeruginosa, Escherichia Coli y especies de proteus. Hubo buena correlación entre los resultados de sensibilidad antibiótica para los cultivos de secreción superficial y aspirados en tejidos profundos