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2.
RBCF, Rev. bras. ciênc. farm. (Impr.) ; 38(2): 183-190, abr.-jun. 2002. ilus, tab, graf
Article in English | LILACS | ID: lil-333582

ABSTRACT

The aim of this study was to describe the double peak plasma pharmacokinetic profile of ranitine after oral administration to healthy volunteers using non-compartmental and compartmental analysis. A single 300mg dose of ranitide was given to ten healthy volunteers (5 male and 5 female). Blood samples were drawn at different times and analyzed by HPLC. Plasma profiles were evaluated by non-compartmental and compartmental approaches. The non-compartmental parameters determined were k (0.0054 ñ 0.0010 min-1), t 1/2 (2.2 ñ 0.4 h), Vd steady state/F (265.3 ñ 70.6L), Cl/F (84.8 ñ 24.3 L/h) and AUC (225916 ñ 54099 ng*min/mL)...


Subject(s)
Humans , Female , Adult , Gastric Acid , Digestive System , Plasma , Ranitidine , Administration, Oral , Blood Specimen Collection , Chromatography, High Pressure Liquid/methods
4.
In. Escola Paulista de Medicina. Departamento de Psicobiologia. Centro de Pesquisa em Psicobiologia Clínica, coord. Encontro de centros brasileiros de tratamento de dependência de drogas. s.l, s.n, 1989. p.1-16, tab.
Non-conventional in Portuguese | LILACS | ID: lil-80555
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