ABSTRACT
Background: Santiago is a city with a high degree of environmental pollution caused by particulate matter and ozone, producing adverse effects in the respiratory system. Aim: to compare respiratory symptoms and cough reflex in adults from Santiago and from a rural area with low levels of environmental pollution. Subjects and methods: one hundred twenty six non smoker adults from Santiago and 116 from a rural area with low levels of pollution answered a respiratory symptoms questionnaire. Of these 101 subjects from Santiago and 116 from the rural area inbaled doubling concentrations of capsaicin from 0.5 to 500 µM or until five coughs were elicited. The lowest concentration eliciting 2 or more coughs (CD2) or 5 or more coughs (CD5) was recorded. Levels of environmental particulate matter were also recorded in both locations. Results: Levels of particulate matter were 102 ñ 41 an 64 ñ 24 µg/m3 in Santiago and the rural area respectively. People from Santiago had higher rates throat clearing, cough and pblegm. CD2 geometric mean and confidence limits in Santiago and the rural area were observed between both locations. Multivariate analysis disclosed the variable location (city) as the only independent predictor of respiratory symptoms. Conclusions: the increased CD2 found in Santiago suggests that the higher rates of respiratory symptoms related to air pollution can be associated to a decreased sensitivity of the cough reflex
Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Respiratory Tract Diseases , Cough , Environmental Pollution/adverse effects , Capsaicin , Air Pollutants/analysis , Meteorological Concepts , Bronchial Provocation TestsABSTRACT
Se presenta el caso de una paciente portadora de una Enfermedad de Basedow que desarrolló bloqueo aurículo ventricular (AV) completo sintomático, requiriendo de la instalación de sonda marcapaso transitoria. En ella existía sólo el antecedente de infección de faringe previo. La conducción AV fue normal una vez eutiroídea. Se señala lo comunicado en la literatura en relación a la génesis del trastorno. Se destaca la importancia de evitar fármacos que puedieran aumentar el deterioro de conducción en aquellos pacientes hipertiroídeos con PR largo y prescindir de terapia definitiva ya que invariablemente se normaliza la conducción AV al lograr eutiroidismo