ABSTRACT
Premature ovarian failure has an overall prevalence of 0.3 percent to 0.9 percent in general population. If fertility is a concern, treatment usually consists of estrogen therapy as hormone replacement and oocyte donation. Spontaneous pregnancy in affected women is uncommon. We report a case of a 34-year old woman, who had premature ovarian failure and primary hypothyroidism, and conceived spontaneously eleven years after the development of premature ovarian failure and correction of hypothyroidism.
A falência ovariana prematura tem uma prevalência global variando de 0,3 por cento a 0,9 por cento na população em geral. Nos casos em que existe preocupação com a fertilidade, o tratamento geralmente consiste de terapia de reposição hormonal com estrógeno e doação de oócitos. A gravidez espontânea em mulheres afetadas não é comum. Relatamos um caso de uma mulher de 34 anos de idade que apresentou falência ovariana prematura e hipotireoidismo primário e concebeu espontaneamente onze anos após o desenvolvimento da falência ovariana prematura e da correção do hipotireoidismo.
Subject(s)
Female , Humans , Pregnancy , Hypothyroidism/drug therapy , Pregnancy Complications , Pregnancy Outcome , Primary Ovarian Insufficiency/drug therapy , Estrogen Replacement Therapy , Hypothyroidism/diagnosis , Primary Ovarian Insufficiency/diagnosis , Thyroxine/therapeutic useABSTRACT
This study was conducted to find out the prevalence of hypertension in newly diagnosed patients with type 2 diabetes mellitus. Five hundred patients (229 men and 271 women) with type 2 diabetes mellitus diagnosed in the last 6 months were evaluated for hypertension and presence of various diabetes related complications. Overall 42% (210/500) of the patients had hypertension; more women (46.1%) than men (37.1%) were affected. Patients with hypertension were older, had higher body mass index and plasma triglyceride levels, and evidence of ventricular hypertrophy on electrocardiogram. Female sex, higher age, family history of hypertension or diabetes, history of neuropathic pains, higher body mass index, presence of albuminuria, dyslipidaemia or cardiac hypertrophy were found to affect prevalence of hypertension in newly diagnosed patients with type 2 diabetes mellitus.
Subject(s)
Adult , Aged , Diabetes Mellitus, Type 2/complications , Female , Humans , Hypertension/epidemiology , India/epidemiology , Male , Middle Aged , Prevalence , Risk FactorsABSTRACT
The term 'prediabetes' has been used to describe the condition in which blood glucose levels are higher than normal but not yet diabetic and includes the two abnormalities, impaired glucose tolerance (IGT) and impaired fasting glucose (IFG). Subsequent to the American Diabetes Associaton (ADA) recommendation to adjust downward the normal fasting glucose level from 110 to 100 mg/dl, the prevalence of IFG has increased by 2 to 4 fold. The demonstration by recent randomised controlled trials that type 2 diabetes mellitus is preventable has raised hope for the possibility of reducing cardiovascular morbidity and mortality associated with diabetes. Interventions like lifestyle modification and pharmacological therapy are recommended in individuals with prediabetes to achieve the goal of prevention of diabetes in high -risk population.