ABSTRACT
Growing evidence indicates that serum Anti-mullerian hormone [AMH] levels could be of great importance for understanding the relationship with oocyte quality for IVF. The aim of the present study was to investigate the role of serum level of AMH in differentiation of infertile female patients with good quality oocytes, who are good responder and ready to enter the IVF cycles. This study included 25 infertile females classified into two groups: [15] females with Tubal obstruction and 10 females with polycystic ovary syndrome [PCOS]. Also, nineteen fertile females were served as controls. Investigation included serum measurements of AMH, Inhibin B, FSH, LH, E2, Prolactin and TSH on day 3 of previous menstrual cycle, serum measurement of progesterone [P4] on day 21 of previous menstrual cycle [before starting ovulation induction]. Also AMH, Inhibin B and E2 were measured on day of hCG administration [after long ovulation protocol]. The mean [ +/- SD] value of serum AMH was significantly decreased in female patients after ovarian stimulation protocol compared to that before ovarian stimulation,[P< 0.01]. Also, the mean [ +/- SD] value of serum AMH of female patients with good quality oocyte was significantly higher than that of those with bad quality oocyte, [P<0.01]. This study revealed that measurement of serum AMH is good marker in prediction of good responder infertile females for IVF technique after ovarian stimulation protocol
Subject(s)
Humans , Female , Anti-Mullerian Hormone/blood , Infertility, Female , Polycystic Ovary Syndrome , Fallopian Tube Diseases , Oocytes , Treatment OutcomeABSTRACT
Serum thyroid hormone level can provide a quantitative index for evaluating the severity of chronic heart failure. To assess the contributions of thyroid hormones [tri-iodothyronine] [T3]and thyroxine [T4]] to the left ventricular [LV] dilatation and myocardial dysfunction in patients with idiopathic dilated cardiomyopathy [IDC]. Forty patients with idiopathic dilated cardiomyopathy [IDC] aged 46.20 + 1.90 years, as [mean +/- SEM] [11 females and 29 males] were studied. Serum total T3, total T4 and thyroid-stimulating hormone [TSH] were measured in these patients. Echocardiographic parameters including LV systolic diameter, septal thickness systolic diameter, LV diastolic diameter, septal thickness diastolic diameter and LV ejection fraction [L VEF] were also be assessed in all patients. This study showed that the serum T4 values were significantly directly correlated with the values of EF% [r = 0.34; P < 0.035] along with significant inverse relationship between serum levels of T3 and the diameter of LV systole [r = - 0.34; p< 0.032]. This study revealed an important significant correlation between serum thyroid hormones levels and echocardiographic parameter values that may point to the role of these biochemical factors in the contribution to the LV dilatation and cardiac dysfunction [heart failure]
ABSTRACT
It has been speculated that trace elements may play a role in the pathogenesis of dilated cardiomyopathy [DCM] .In the present study, we aimed to assess serum concentrations of selenium [Se] in Iraqi patients with idiopathic dilated cardiomyopathy [IDC] and to evaluate the correlation between serum Se concentrations and echocardiographic parameters. This study included 28 patients with IDC and 22 healthy controls .Serum level of selenium was measured by atomic absorption spectrophotometry method .Echocardiographic parameters including left ventricular end diastolic diameter [LVEDD], LV end- systolic diameter [LVESD], and LV ejection fraction [LVEF] were measured in all patients with IDC in order to evaluate its correlation with serum Se concentrations. Serum concentration of Se in IDC patients was significantly lower than in healthy controls [p<0.001].Relationships of the serum Se levels with echocardiographic and clinical parameters were not statistically significant. The present study confirmed that IDC is associated with decreased serum Se concentrations. This change in Se may play an important role in the pathogenesis of myocardial damage in IDC
ABSTRACT
There is a suggestion that abnormal coronary physiology may be exist early in the course of idiopathic dilated cardiomyopathy [IDC], and is likely to play an important role in the pathogencsis and progression of the myopathic state in such patients. With regard to lipid profile, high-density lipoprotein cholesterol [HDL-C] particle enhances NO production and improves endothelium relaxation. This study included 50 patients aged 19-72 years [13 females and 37 males] with IDC and 23 healthy controls aged 29 to 60 years [9 females and 14 males]. Lipid profile, should be at least 12 hours fasting, including serum total cholesterol, high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C] and triglyceride [TG] were evaluated in these two groups. Measurements of some of echocardiographic parameters including left ventricular [LV] systolic and diastolic diameters, and LV ejection fraction [LVEF] in IDC patients, and correlate its values with each one of the above lipid parameters in order to define the more predictor lipid parameter in evaluating the structure and function of the heart. The mean values of serum total cholesterol and LDL-C were insignificantly higher in patients with IDC patients than in controls. The mean of serum HDL-C was significantly low in IDC group against controls [P< 0001]. The mean [ +/- SEM] serum triglyceride TG levels in patients with IDC was significantly increased when they were compared to that of normal controls [P< 005]. An important inverse relation was observed between serum levels of H DL-cholesterol and LV diastolic diameter values [r= - 0.29, P< 0039] as well as between HDL-cholesterol levels and LV systolic diameter values [r= - 0.33, P< 0.02]. A borderline significant positive correlation between serum concentrations of HDL-cholesterol and the values of EF% was also shown in the IDC patients [r= 0.28, P< 0.05]. The result of this study may point to the role of HDL-C in contribution to the LV dilatation and myocardial dysfunction [heart failure] in IDC
ABSTRACT
Familial linkage of primary dilated cardiomyopathy [DCM] occurs more commonly than often is appreciated. In J 0-20 percent of patients, a first degree relative also shows evidence of primary DCM suggesting that familial transmission is relatively frequent. This study included 7 patients aged 40-70 years [2 females and 5 males] with familial dilated cardiomyopathy [FDCM] and 17 healthy subjects aged 29-60 years [6 females and 11 males]. Plasma fasting total homocysteine tHCY, serum folic acid [FA], vitamin B6, total triiodothyronine [T3], and total thyroxine [T4] were measured in these two groups. The mean value of plasma tHCY was significantly higher in patients with FDCM than in control [P<0.001]. The mean [ +/- SD] values of serum folic acid and vitamin B6 were significantly decreased in FDCM patients when compared with those of control group [P<0.05, P<0.01, respectively]. A significant inverse relationship between plasma tHCY concentration and the values of serum FA was shown in the FDCM patients [r=-0.78, P<0.05]. The mean values of serum T3 and T4 were insignificantly decreased in patients with FDCM than in controls. The level of plasma tHCY is significantly higher in FDCM patients than in healthy control. This severe hyperhomocyteinemia of FDCM patients may be related to evolution and development of myopathic state in such patients
ABSTRACT
The objective of this study is to shed more light on the role of trace metals and their mode of action in hyperthyroidism. The content of the trace elements [Zn, Cu, Mn, and Se] in the serum of patients was determined and compared to that of normal subjects. Ninety eight [98] patients with hyperthyroidism were participated in this study and fifty normal healthy persons were taken as control. Serum zinc and copper were determined using flame atomic absorption spectrophotometer while serum manganese and selenium were estimated using flameless atomic absorption spectrophotometer technique. The study showed that serum zinc and selenium level of hyperthyroidism patients were significantly lower [p<0.05] than the level in normal subjects. While a significant increase in serum copper level was demonstrated in patients as compared with that of the normal subjects. The results showed no significant difference between the groups [p>0.05] in serum manganese. The present study confirmed a significant changes in the levels of serum Zn, Cu, and Se in hyperthyroidism patients and these changes may be related to pathophysiology of thyroid disease
ABSTRACT
Limited data are available with regard to the relation between maternal and fetal serum lipid and lipoprotein levels and the mode of delivery. The aim of this study is to evaluate the effect of mode of delivery on the levels of serum lipid and lipoprotein of mothers and their umbilical cords. This study is consisted of fourty-nine pregnant women delivered by elective caesarean [CS] and seventy-five age-and gestational age-matched pregnant women who delivered by normal vaginal delivery[NVD].Serum lipid profile parameters including; total cholesterol [Tch], triglyceride [TG], high density lipoprotein-cholesterol [HDL-C] and low density lipoprotem-cholesterol [LDL-C] were measured in the serum of these two groups of pregnant women as well as in the serum of their umbilical cords. The mean [ +/- SEM] values of serum Tch, TG, and LDL-C were significantly higher in pregnant women who delivered by NVD when compared with those of pregnant women delivered by CS[all P< 0.001].With regard to serum HDL-C mean value there was no significant difference between these two groups. Similarily,the mean [ +/- SEM] values of serum Tch, TG, LDL-C were significantly increased in umbilical cord of NVD mothers in comparison with values obtained in umbilical cord of CS mothers[all P< 0.001]. There was also a significant positive relationship between mothers and umbilical cord serum Teh levels in NVD group[r=0.339, P< 0.001]. This study revealed that the mode of delivery, in particular, NVD changes significantly the concentrations of lipid parameters mainly Tch, TG, and LDL-C. Such changes require an important attention postpartumly for such mothers with respect to biochemical investigation, particularly lipid parameters
ABSTRACT
Liver biochemical tests regarding serum aminotrasnsfereases [AST, ALT], alkaline phospahatases[ALP], lactate dehydrogenase [LDH], gamma glutamyltransferase [GGT], cholesterol, total and conjugated bilirubin, total proteins and electrophoretic fractions were measured in 59 diabetic patients with hepatomegaly and a control group of 50 subjects without diabetes or hepatomegaly. Significant increases of SAST, SALT, SALP, SLDH, SGGT, and serum cholesterol were found in diabetics with hepatomegaly as compared to the diabetic with no hepatomegaly and the control group. There was also significant difference between total serum bilirubin concentration in hepatomegalic diabetics and controls, but no significant difference with those diabetic patients with normal liver size. The Level of serum albumin was significantly lower while alpha[1], alpha[2], beta and total globulins were significantly higher in hepatomegalic diabetics than in the control group