ABSTRACT
Context: Hyperlipidemia is frequently common in uremia and persists after successful renal transplantation [RT]. It is one of the risk factor for the development of atherosclerosis in RT recipient and has a deleterious effect on graft function
Objective: To assess the prevalence of hyperlipidemia in RT in Mosul and to determine its types
Design: Prospective study of hyperlipidemia in RT using clinical and laboratory investigation of their lipid profile, renal function, serum glucose, proteinuria and immunosuppressive therapy
Setting: The study was conducted in the out patient nephrology clinic at lbn Sina teaching hospital between June 2000 November 2001 who had RT
Participants: Seventy eight of RT patients, [44] males and [34] females, with a mean age of [38] years and age range of [11-55] years transplanted within a period of 3 months 17 years were included. Fifty apparently healthy subjects, [26] males and [24] females, of normolipidemic state were taken as a control group
Results: Different types of hyperlipidemia were detected. hypercholesterolemia in 58.9%, combined hyperlipidemia in 62.8%; i.e., increase in both total cholesterol [TC] and triglycerides [TG]. Higher total cholesterol, low-density lipoprotein cholesterol [LDL-C], very low-density lipoprotein [VLDL-C] and serum triglycerides were encountered in patients with RT less than one year compared with those with RT more than one year. Higher TC, VLDL-C, TG seen in chose receiving triple immunosuppressive therapy [cyclosporine. corticosteroid and azathioprino] than those on dual therapy [corticosteroid and azathioprine]. The effect of acute rejection on serum lipid variable of RT patients is well established. The causes and the explanation were discussed
Conclusion: Hyperliprdemia is prevalent after RT, further investigations are needed to determine whether graft losses and late graft failure can be prevented or ameliorated by treating hyperlipidemia