ABSTRACT
HIV/syphilis co-infection is common because both conditions affect similar risk groups. HIV interferes with the natural history of syphilis, which often has atypical clinical features and nervous system involvement in the early stage of disease. We report the case of an HIV-positive patient with secondary syphilis, scaling palmoplantar keratoderma, scrotal eczema, balanitis and urethritis mimicking Reiter’s syndrome. Immunohistochemistry using polyclonal antibodies against Treponema pallidum revealed the presence of spirochetes, associated with the paretic form of parenchymal neurosyphilis. The patient was given crystalline penicillin, with complete resolution of dermatological and neurological symptoms, and no sequelae.
.Subject(s)
Adult , Humans , Male , Arthritis, Reactive/pathology , Coinfection/pathology , HIV Infections/pathology , Neurosyphilis/pathology , Anti-Bacterial Agents/therapeutic use , Biopsy , Diagnosis, Differential , Immunohistochemistry , Keratoderma, Palmoplantar/drug therapy , Keratoderma, Palmoplantar/pathology , Neurosyphilis/drug therapy , Penicillin G/therapeutic use , Treatment OutcomeABSTRACT
Synovial sarcomas are rare malignant tumors affecting mainly young adults, presenting as a slow growth mass located in deep soft tissues of extremities, near the joints. In this report a 34-year-old male patient, presented an ulcerovegetative lesion on the right wrist which was completely excised. Histopathology and immunohistochemistry confirmed synovial sarcomas with poorly differentiated cells. This patient presented 11 months later with ipsilateral axillary lymph node metastasis, which emphasizes the unfavorable prognosis of this synovial sarcoma variant. The indolent growth pattern of this sarcoma justifies the well circumscribed initial stages, which progressively infiltrate adjacent structures with lung metastasis (80%) and lymph node involvement (20%) and thus corroborates the importance of early diagnosis and proper treatment.
Subject(s)
Adult , Humans , Male , Sarcoma, Synovial/pathology , Skin/pathology , Soft Tissue Neoplasms/pathology , Wrist , Biopsy , ImmunohistochemistryABSTRACT
Chromoblastomycosis is a chronic subcutaneous mycotic infection caused by dematiaceous saprophytic moulds. The most frequently isolated agent is Fonsecae pedrosoi. This article reports a case of a man from the Amazon region in Northern Brazil who presented with a lesion of 12 months' duration, which gradually increased in size until covering the majority of his right leg. A successful treatment with itraconazole was performed.