ABSTRACT
A series of 2-oxo-N'-phenylmethylidene-2H-chromene-3-carbohydrazides and their thiazolidinone derivatives were designed on the basis of pharmacophoric distance mapping study of well established anticonvulsant drugs. In another computational study, pharmacokinetic parameters of designed compounds were predicted using Molinspiration Online Property Calculation Toolkit. Structures of all the compounds were confirmed by spectroscopical data. Compounds were evaluated for neurotoxicity by rotorod test. Anticonvulsant activity of test compounds was evaluated by maximal electroshock seizure (MES) animal model of seizures. Test compounds CS-6 and CST-6 were found to possess potent anticonvulsant activity and served as the prototype molecules of the series.
ABSTRACT
The present study aims to investigate the antidiabetic activity of roots of Cayratia trifolia (L.) Domin in alloxan induced diabetic rats. Phytochemical studies showed the presence of steroids, flavonoids and alkaloids in petroleum ether, ethyl acetate and ethanol extracts, respectively. Antidiabetic activity was evaluated by observing blood glucose levels and analyzing the serum biochemical parameters after dosing the ethyl acetate extract. Blood samples were collected from overnight fasted diabetic rats on 5, 10 and 15 days of treatment to determine blood glucose levels. On day 16, blood samples were collected to estimate the biochemical parameters. In diabetic rats, both the doses (200 mg/kg and 400 mg/kg) of ethyl acetate extract were found to be significant (P<0.05) when compared with control and favourable changes in biochemical parameters were also observed. It can be concluded from the study that the ethyl acetate extract of roots of C. trifolia possess potent antidiabetic activity.