ABSTRACT
Background: C-peptide and insulin are secreted by pancreatic beta cells in equimolar concentrations. C- Peptide is associated with increased risk of cardiovascular disease. Methods: Routine outpatient department patients were investigated for serum C-peptide, Diabetes, Ischemic heart disease, hypertension and skin lesion acanthosis negrican. Results: Total ninety five patients enrolled in study of these peptide level 2, 2 to5 and >5 found in 22,46,27 patients respectively, with diabetes mellitus in 21 (95%), 39(55%) and 24 (89%), ischemic heart diseases 1(5%), 15(33%), 13(48%) , hypertension 9(41%), 20(44%), 12(45%), acanthosis negrican 9 (41%), 27 (59%), 21 (78%), family history 1 (5%), 18 (39%), 11 (41%) respectively. Conclusion: Significant incidence of hypertension and ischemic heart disease is related to raised level of circulating C-peptide
ABSTRACT
he present study is an attempt to evaluate the clinical manifestations of severe scorpion sting in children and their management at a rural setting. Twelve patients with severe scorpion sting referred from primary health center are presented in this report. Eight children had pulmonary edema and hypotension; two had pulmonary edema and hypertension while one each presented with hypertension and tachycardia in isolation. Oral prazosin, dobutamine infusion and sodium nitroprusside drip (SNP) were used as therapeutic options based on the symptomatology. Two children died of massive pulmonary edema despite use of SNP and dopamine drip. Anti scorpion venom did not prevent the cardiovascular manifestations of severe scorpion sting. Early administration of prazosin alleviated the severity of scorpion envenomation