ABSTRACT
Objective To investigate the effect of vancomycin on neonatal sepsis and its clinical effect . Methods The clinical data of 67 children with methicillin resistant Staphylococcus aureus (MRSA) infection and septicemia treated in the hospital from January 2010 to January 2017 were reviewed .The children were treated with ceftazidime+piperacillin/sulbactam when they did not diagnosed with MRSA infection .The chil-dren were treated with vancomycin when they diagnosed with MRSA infection .The immunological and inflam-matory indexes of children before and after vancomycin treatment were compared ,and the clinical effects and adverse reactions were evaluated .Results After vancomycin treatment ,the serum IgG and NK cell activities in 67 children were significantly higher than those before vancomycin treatment (P<0 .05) ,the level of IgM in children was lower than that before treatment ( P< 0 .05) .After treatment ,the serum levels of IL-6 ,IL-8 , IL-2 ,sIL-2R ,CRP ,TNF-α,PCT ,WBC in 67 children were significantly lower than those before treatment (P<0 .05) .The total effective rate of vancomycin treatment was 89 .55％ ,which was higher than that without vancomycin treatment (58 .21％ ,P< 0 .05);the occurrence of adverse reactions before and after treatment with vancomycin were 19 .40％ and 23 .88％ ,and the difference was not statistically significant (P>0 .05);the children of two groups did not appear serious adverse reactions during treatment ,they were treated by symp-tomatic treatment or respite medication ,and continue treated after symptom relief .Conclusion Vancomycin in the treatment of neonatal septicemia caused by M RSA infection can significantly improve the immune level of children ,reduce the degree of systemic inflammatory response ,and the treatment effect is better .