ABSTRACT
Background and Aims: Chromosome abnormalities are a major cause of miscarriage and neonatal mortality. The present study aimed to determine the association of fetal and parents chromosomal abnormalities with congenital anomalies
Methods: A cross-sectional study was performed in a tertiary referral center [Afzalipour Hospital] over 16 months period [2011-2012]. The study groups consisted of 77 fetuses over 14 weeks and their parents. Fetuses had apparent anomaly after abortion or birth, or showed a defect organs in targeted sonographic examination. DNA extractions were from fetus tissues for investigation of chromosome abnormalities using [multiplex ligation-dependent probe amplification] MLPA. Cytogenetic analysis for parents was performed with G-banding technique. Eventually data were analyzed by statistical software SPSS using t-test, chisquare and logistic regression
Results: Karyotyping of fetus was 46xx in 27 [35.9%] and 46xy in 25 [32.1%] cases. Twenty-five fetuses had chromosomal abnormalities. The common chromosomal abnormalities were multiple deletion and duplication on different chromosomes in 4 [6.5%] and Down syndrome in 3 [3.9%] of them. This study showed a statistically significant association between the extremity anomalies [P=0.0070], oligohydroamnious [P=0.0050], ascitis [P=0.0001], increased nuchal translucency [P=0.0001], esophageal atresia [P=0.0070], duodenal atresia [P=0.0001], polycystic kidney [P=0.0070], echogenic bowel [P=0.0001], plural effusion [P=0.0001] and cardiomegaly [P=0.0010]. There were no statistically significant association between the chromosomal abnormalities in fetus and parents [P=0.5700]
Conclusion: In our study, there was no association between the chromosomal abnormalities in fetus and parents. It can be concluded that many chromosomal defects occur during the formation of sperm or ovum. Detection of major congenital malformations should draw attention to the possibility of a chromosomal disorder in fetus. Therefore, MLPA is a low cost method for detecting a wide range of the most common chromosomal disorders in a short time
ABSTRACT
Disability in the elderly period is result of different factors which inactivity and incorrect use of muscle are the most trigger. Applying of activity programs can improve elderly women's quality of life. This study investigates the effect of exercise on elderly women quality of life in jahandidegan club foundation in 2007. This study is a quasi - experimental research that was carried out in jahandidegan club foundation for elderly women, in 2007. Population of this study was 400 elderly women which of this numbers 232 elderly women aged 60 - 79 years were allocated to two groups of experimental [n=116] and control [n =116] with randomized permuted block. Instrument for data collection was client demographic characteristics and leipad questionnaire. The client in experimental group received 30 minutes of exercise for 24 consecutive days during 6-7 mornings. Quality of life measured in both groups before and after intervention. Data were analyzed by use of chi - esquare, independent statistical test [T test], kolmogorov - smornov test, Mann Whitney test, pair t-test, wilcoxon and covariance analysis. Mean of quality of life before of exercise in experimental group was 70/60 and control group was 70/99. After exercise mean of quality of life in experimental group was 75/80 and control group was 70/64. Different between two group was significant in 95% level [p = 0/13]. According to the result, exercise was effective to increase elderly women quality of life levels, therefore it can be used as simple and complementary method for improving women elderly quality of life