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Indian J Exp Biol ; 1990 Sep; 28(9): 862-7
Article in English | IMSEAR | ID: sea-57253

ABSTRACT

Genotoxic effect of isoproturon was assessed by employing in vivo chromosomal aberration, micronucleus and sperm-shape abnormality assays. A significant dose-responsive mutagenic effect was observed in chromosome aberration and sperm-shape abnormality tests whereas in micronucleus assay the effect was significant only at the highest dose (200 mg/kg). Only the result for the chronic dose and the two different fixation times (6 and 48 hr) were not statistically significant. The results indicate the genotoxic property of isoproturon in mammalian in vivo test system.


Subject(s)
Analysis of Variance , Animals , Bone Marrow Cells , Chromosome Aberrations , Herbicides/toxicity , Male , Methylurea Compounds/toxicity , Mice , Micronucleus Tests , Mutagenicity Tests , Mutation , Phenylurea Compounds , Spermatozoa/abnormalities
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