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1.
Article in English | IMSEAR | ID: sea-148389

ABSTRACT

To assess the clinical safety of equine rabies immunoglobulin (ERIG) and purified vero cell rabies vaccine (PVRV) administered intradermally in children for post-exposure prophylaxis against rabies, a study was carried out among 1494 children <15 years of age having category III exposure to animal bite at the antirabies clinic of community medicine department of MKCG Medical College Hospital, Berhampur, Orissa from 1st May 2007 to 31st March 2008. The patients received 0.1 ml of PVRV intradermally at two sites on days 0, 3, 7 and 28. The PVRV (Abhayrab) supplied by Government of Orissa had an antigen content of > 2.5 IU per 0.5 ml vial. ERIG (Equirab) was also given on day 0 as per WHO guideline. As much of the immunoglobulin as possible was infiltrated around the wounds after skin test. Side effects were monitored during the follow up visits on days 3, 7 and 28. One hundred & eight children (7.2%) showed positive reaction to the skin test dose of ERIG. These patients could not afford HRIG and were administered ERIG after premedication with oral antihistamine (Levocetrizine). There were no serious systemic side-effects but local side-effects like induration, erythema, pruritus are due to the intradermal rabies vaccination (IDRV) and pain, induration due to ERIG. Low grade fever and malaise were the only systemic side effects observed. None of the children had anaphylaxis or regional lymphadenopathy. Only 3% of children had mild serum sickness like symptoms by days 5 & 7 which subsided with oral analgesics and antihistamines. Our study showed that administration of ERIG & PVRV by intradermal route in children with WHO category-III rabies exposure is safe.

2.
Indian J Public Health ; 2005 Oct-Dec; 49(4): 241-2
Article in English | IMSEAR | ID: sea-109167

ABSTRACT

A hospital based study was conducted in the anti-rabies clinic of a medical college of Orissa during April 1988 to May 2002. Of 24 clinically diagnosed and reported rabies cases during the four years study period, 62.5% were children below 15 years of age, 67% were males, 87.5% were victims of stray dogs, 79% had not taken any anti-rabies treatment though all had undergone treatment by traditional systems of medicine.


Subject(s)
Adolescent , Ambulatory Care Facilities/statistics & numerical data , Animals , Bites and Stings/complications , Child , Dogs , Drug Utilization , Female , Health Education , Hospitals, Teaching , Humans , India/epidemiology , Male , Medicine, Traditional , Rabies/epidemiology , Rabies Vaccines/therapeutic use , Socioeconomic Factors , Zoonoses/epidemiology
3.
J Indian Med Assoc ; 2005 Apr; 103(4): 238, 241-2
Article in English | IMSEAR | ID: sea-101353

ABSTRACT

To confirm and assess the clinical safety of equine rabies immunoglobulin (ERIG) administered locally for postexposure prophylaxis against rabies since human rabies immunoglobulin is too expensive to be affordable by most patients, a study was carried out among 3723 patients who attended the antirabies clinic, department of community medicine, MKCG Medical College Hospital, an urban tertiary hospital between September 1, 2003 and March 31, 2004. They were advised ERIG, 1621 patients were of high risk due to the nature of the bites or animal, but only 286 patients of them who could afford the treatment received it. Side-effects were monitored during the follow-up visits on days 3,7,14,30,60 and 90. Statistical analysis was done by using simple proportions and chi-square test. Of the 286 cases receiving antirabies treatment, 214 patients had dog bites and in 100 cases the animal showed abnormal behaviour. Pain (n=237) was the most common side-effect and in 18 patients fever was the systemic side-effect. No anaphylaxis was noted in the study. On day 90 none of the patients had developed rabies. So it can be concluded that ERIG is safe for passive immunisation against rabies.


Subject(s)
Adolescent , Adult , Animals , Chi-Square Distribution , Female , Horses , Humans , Immunoglobulins/therapeutic use , India/epidemiology , Male , Middle Aged , Rabies/epidemiology , Rabies Vaccines , Rabies virus/immunology , Treatment Outcome
4.
Indian J Lepr ; 2002 Oct-Dec; 74(4): 335-40
Article in English | IMSEAR | ID: sea-54515

ABSTRACT

The Government of Orissa implemented the Revised Operational Strategy in September 1999 to integrate the NLEP functions into primary health care activities. An interventional strategy, in the form of consensus on job responsibilities and capacity-building through training of PHC staff, was developed and adopted in a rural block under the Department of Community Medicine to strengthen the integration process. The impact was studied six months after the intervention by comparing it with the leprosy situation in the pre-intervention period. Data were collected by verification of registers at the block PHC and sub-centre levels. Analysis was done using different leprosy indices, such as new case-detection rate (NCDR), child rate, deformity rate, profile of leprosy cases and patient compliance, etc. This integrated approach was found to be more community-oriented and effective in early case-detection in children and women. It also helped in providing continuous MDT services because of the involvement of primary health care functionaries in the post-intervention period.


Subject(s)
Adult , Child , Community Medicine/organization & administration , Delivery of Health Care, Integrated , Female , Humans , India , Leprosy/prevention & control , Male , National Health Programs , Primary Health Care/organization & administration , Program Development , Program Evaluation , Rural Health
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