ABSTRACT
Endometrial cancer is the most frequent cancer in the female genital system. Nowadays outpatient diagnostic procedures like pipelle and uterobrush have facilitated the diagnosis and treatment of endometrial cancer in early stages in high-risk patients. This study has been done to compare the accuracy and tissue sufficiency of biopsy by pipelle and uterobrush. Between 2005 and 2007, 70 candidates admitted for hysterectomy in Imam Hossein Hospital entered a clinical trial study. Under local or general anesthesia, biopsies were taken by pipelle and then uterobrush or vice versa. The order of using pipelle and uterobrush was selected randomly. The samples were sent to the pathology department and examined by an expert pathologist. The results of endometrial biopsies by pipelle and uterobrush were analyzed. After that the cases were grouped [each group consisted of 35 patients] according to the order of using the pipelle and uterobrush. The endometrial samples sufficiency from uterobrush and pipelle were 68.1% and 87.1%, respectively. The positive predictive value of pipelle was 100% and negative predictive value was 84%. These values for uterobrush were 100% and 90% respectively. It seems that pipelle is better for obtaining sufficient size samples. However in sufficient samples, uterobrush has higher sensitivity and accuracy. Order of using pipelle and uterobrush caused no significant difference in the results