ABSTRACT
GranymeH is a functional cytotoxic serine protease of NK cell granules,which expands the cell death-inducing repertoire of innate immune system.The purpose of this study was to determine GranymeH[GZMH]level in breast cancer[BC] and healty women.This study was performed on 30 patients with BC and 30 healty woman.GZMH and Estrogen levels were measured in cancer patients and healty women subsequently using ELISA and Radioimmunoassay[RIA] methods. Mean GZMH value was lower in BC than healty women[p<0.0001] and mean Estrogen level was higher in BC patients in comparison to healty women [p<0.003].Our finding indicates probability of existance of suppressor or a problem in production of GZMH in cancer patients
ABSTRACT
Perforin[p] is the primary mediator of short term cytotoxicity, it is accumulated in response to proinflammatory cytokines and stored in T lymphocyte, NK cells and NKT cells are released upon activation. Perforin is a prototypical cytotoxic molecule involved in cell mediated immunity against various pathogens, alloantigens and particularly different tumors.The purpose of this study was to determine perforin level in prostate cancer [P.Ca] and Benign Prostatic Hyperplasia [BPH] This is study was performed on 59 patients consisting of 28 patients with P.Ca and 31 patients with BPH.Perforin and PSA levels were measured in cancer and BPH patients using ELISA method. Mean Perforin value was significantly lower in P.Ca patients than in BPH patients [p < 0.01] where as mean serum PSA level was significantly higher in the cancer patients in comparison to the BPH group [P < 0.01 Our finding indicate probability of problem in expression of cytotoxic molecule ,perforin in and around the tumor