ABSTRACT
Objective: to evaluate the efficacy of the combination therapy of mometasone and pimecrolimus in the treatment of vitiligo in children
Methods: in this double-blind randomized controlled trial, 50 patients were enrolled. Based on the planned treatment protocol, three lesions with approximately identical size at similar anatomic sites were selected in each patient. Lesions were divided to three groups: pimecrolimus cream 1 % [twice a day], mometasone furoate ointment 0.1 % [every night], and combined therapy group [pimecrolimus twice a day on weekdays and mometasone every night on weekends], all being applied for three months. They were followed up for three months
Results: forty patients [with 46% of cases being male] with a mean age of 10.6 years completed the study. There was no significant difference in response rate between three groups at the end of the treatment
Conclusion: our study results did not demonstrate significant difference in the response rate and adverse effects between combined treatment group and either alone
ABSTRACT
To evaluate the presence of Sinti-Helicobacter pylori antibody in the sera of children with and without atopic dermatitis [AD] in Kerman province, Iran. In the current study the cases consisted of 128 patients with AD, aged from 6 month to 16 years. One hundred and twenty eight healthy children matched for sex and age were chosen as control subjects. The enrolled patients were selected consequentially from the cases referred to the dermatology and pediatric clinics of Afzalipour hospital, an academic medical referral center in the capital of Kerman province. The diagnosis of AD was made based on the UK working party's diagnostic criteria for atopic dermatitis. The control subjects were chosen randomly among children who were referred to the center for periodic vaccination program and before receiving the vaccines. The subjects in control group who had a personal or family history of allergies [including asthma, atopic dermatitis or allergic rhinitis] were excluded as well. A sample consisting of 3 milliliters of blood was obtained from each subject in the study [including the cases and the controls] for H. pylori serology. In children under 1 year of age, the amount of collected blood samples we reduced to the minimum in the acceptable range. The status of infection with Helicobacter pylori was determined in all subjects quantitatively by measurement of specific IgG antibody via enzyme-linked immunosorbent assay [ELISA] method [Trinity Biotech Monbind Captia[tm], USA]. The mean age of the cases with AD and the controls were 5.74 +/- 4.05 and 6.05 +/- 3.36 years, respectively. Of all the children in both cases and controls 45.5% and 55.8% were females, respectively and the remaining were males. Anti-H. pylori IgG antibody was positive in the cases with AD and the control group 25.2% and 24%, respectively that was not statistically significant. The results of this study showed no association between H. pylori infection and AD
ABSTRACT
To assess the prevalence of cardiovascular disease [CVD] risk factors in patients with psoriasis. Patients and methods The study group included seventy-three patients with psoriasis aged 20-50 years and an equally sized sex and age matched control group. CVD risk factors including diabetes mellitus [DM], hypertension [HTN], dyslipidemia, obesity and smoking history were assessed. Results Most of the CVD risk factors were more prevalent in psoriasis patients versus controls. The risk factors with a positive correlation included: DM [OR: 4.96, CI: 1.165-14.89], HTN [OR:3.16, CI:1.01-9.81], hypertriglyceridemia [OR:3.91, CI: 1.51-10.09], obesity [OR: 2.74, CI: 1.34-5.60] and increased level of low density lipoprotein-cholesterol [LDL-C] [OR:1.77, CI:1.08-1.73]. No significant differences were found between two groups for high density lipoprotein-cholesterol [HDL-C] and cigarette smoking. Conclusion CVD risk factors were more common in this young and middle aged psoriasis patients group, so early screening test for CVD risk factors is recommended in this group of patients
ABSTRACT
We describe a 31-year-old man, a known case of hepatitis C infection for 11 years, who presented with a chronic non-healing large deep ulcer on the dorsum of the right foot for five months. Fusarium solani infection was confirmed by skin biopsy and culture. The biopsy specimen showed an unusually extensive dermal invasion with fungal hyphae. The patient's response to oral itraconazole 100 mg/day for 3 months was excellent. Closed monitoring of liver enzymes was done before and during the treatment course