validity of MRI in evaluation of tumor response to neoadjuvant chemotherapy in locally advanced breast cancer

Physical Examination [PE] and breast MRI are two of the current methods which have usually used in diagnosis of primary breast cancer. Their accuracy in detection of: either complete response or presence of residual tumor, however, has not yet been established in patients who have been received Neoadjuvant Chemotherapy [NAC]. The purpose of this study was to evaluate the diagnostic accuracy of breast MRI in assessment of residual neoplastic tissue after NAC in patients with Locally Advanced Breast Cancer [LABC]. Twenty patients with LABC have undergone contrast-enhanced MRI before and after the NAC. Considering histology as the gold standard, the tumor sizes in MRI and PE have compared with the histology results. We have calculated for all below: the accuracy, sensitivity, specificity, Positive Predictive Value [PPV] and Negative Predictive Value [NPV] for each of MRI and physical examination, as well as Pearson's correlation coefficients between the results of MRI and PE, and their histology results. We have found an accuracy of 85% for MRI with a sensitivity of 100%, a specificity of 50%, a PPV of 83.3%, and an NPV of 100%. In addition, the accuracy for PE was 70% with a sensitivity of 71.4%, a specificity of 66.6%, a PPV of 83.3%, and an NPV of 50%. In this study, the calculated Pearson's correlation coefficient for MRI and histology was 0.817 [p<0.0001] versus 0.26 [p=0.26] for correlation between PE and histology. MRI has higher sensitivity but less specificity than PE for detection of residual tumor after NAC in locally advanced breast carcinoma. Also, the tumor size that has measured by MRI had highly correlation with the histology

Comparison of clinical and sonographic prevalence of developmental dysplasia of the hip

Developmental dysplasia of the hip [DDK] is one of the most widely discussed abnormalities in neonates. The advantages of sonographic examination are well known, but its main disadvantage is that it might lead to over diagnosis, which might cause over treatment. Variations in the incidence of developmental dysplasia of the hip are well known. During six months study since September 2006 all 1300 neonates [2600 hips] were born in our hospital examined clinically and sonographically [587 hips] in the first 48 hours of life. Sonography was performed according to Grafs method, which considers mild hip sonographic abnormalities as type II a. Type IIb Graf were considered pathologic. Sonography screening of 587 hips detected 36 instances of deviation from normal indicating a sonographic DDH incidence of 12.5%. However, only 8 neonates remained abnormal and required treatment, indicating a true DDH incidence of 6 per 1000 live birth. Risk of diagnosis clinically and sonographicaly were 2.5 and 4.5 percent respectively and was significant [P<0.00001, x[2]=l 170]. In order to avoid over diagnosis in first days examination, repeated clinical and sonographic examination is required