ABSTRACT
Objetive To study the value of urinary neutrophil gelatinase associated lipocalin (NGAL) in predicting carotid atherosclerosis in elderly type 2 DM patients.Methods Two hundred and twenty-five elderly type 2 DM patients were divided into urinary NGAL≤42 ng/mg group (n=100) and urinary NGAL＞42 ng/mg group (n=125).Their clinical data were retrospectively analyzed.Risk factors for carotid atherosclerosis were recorded.The value of risk factors in predicting carotid atherosclerosis was assessed according to the area under the ROC curve.Results The incidence of carotid atheroslerotic plaques was significantly lower in urinary NGAL≤42 ng/mggroup than in urinary NGAL＞42 ng/mg group (32.0％ vs 57.8％,P＜0.05).Age,NGAL,urinary microalbumin/creatinine (ACR),LDL-C,TC,hypertension were positively related with carotid atherosclerosis (P＜0.05) and eGFR was negatively related with carotid atherosclerosis (P＜0.05).Urinary NGAL and ACR were two risk factors for carotid atherosclerosis after adjustment for age,hypertension,hyperlipidemia,and eGFR (P＜0.05).The area under the ROC curve for predicting carotid atherosclerosis was 0.87 and 0.78 respectively.Conclusion Urinary NGAL is an independent risk factor for carotid atherosclerosis in type 2 DM patients.The accuracy of urinary NGAL is higher than that of urinary ACR in predicting carotid atherosclerosis.
ABSTRACT
Objective To analyze the risk factors between young and middle-aged patients and oldaged patients with hypertensive cerebral hemorrhage in the Kazakhs of Xinjiang.Methods A retrospective analysis of the 127 cases with hypertensive cerebral hemorrhage in the Xinjiang Uygur Autonomous Region people's Hospital.In addition,171 patients with non cerebral hemorrhage were selected as the control group.All the patients were divided into young and middle-aged group and old-aged group.The risk factors of two groups of hypertensive intracerebral hemorrhage were compared,and two groups of risk factors were analyzed by Logistic regression analysis.Results There were significant differences in diabetes,coronary heart disease,alcohol drinking,disease awareness,treatment compliance,systolic pressure,diastolic pressure,low-density lipoprotein (LDL),high-density lipoprotein (HDL),serum homocysteine (Hcy) and carotid atherosclerosis between the two groups (P ＜ 0.05).Logistic regression analysis showed that the independent risk factors of young and middle-aged patients with hypertensive cerebral hemorrhage in the Kazakhs of Xinjiang included alcohol drinking,treatment compliance,systolic pressure,diastolic pressure and Hcy (P ＜ 0.05),but systolic pressure,Hcy and carotid atherosclerosis were the independent risk factors of oldaged patients (P ＜ 0.05).Conclusions There were differences in the risk factors between young and middle-aged patients and old-aged patients with hypertensive cerebral hemorrhage in the Kazakhs of xinjiang,but systolic pressure and Hcy were both the independent risk factors of the two groups.