ABSTRACT
Background: mitochondrial appropriate function depends on ideal mitochondrial translocation machinery, of which translocase of outer mitochondrial membrane [TOMM] have a vital role in normal functioning cell. Any disturbance in the translocation machinery leads to either tumorigenesis or apoptosis
Aim of the work: This study aimed to investigate the expression of TOMM34 in renal cell carcinoma [RCC]. TOMM34 expression was assessed in 42 samples of RCC patients using immunohistochemistry technique
Results: immunohistochemical staining revealed significant accumulation of TOMM34 protein in RCC cases compared to their corresponding non-cancerous renal tissues. TOMM34 protein expression was significantly associated with age and gender categories in contrast to the other clinicopathological features
Conclusion: according to protein expression level this study demonstrated that TOMM34 is a marker of poor outcome in RCC
ABSTRACT
Background: colorectal cancer is considered to be the third most common cause of deaths in both men and women. The incidence of colorectal cancer cases has been rising at an alarming rate. In most cases, colon cancer treatment involves chemotherapy. However, toxicity and tumor cell drug resistance are outstanding obstacles to this treatment. Scientific studies suggested that combining certain chemotherapy treatments with specific antioxidants at defined dosages can improve drug efficacy or may reduce side effects severity.5-Fluorouracil, which is used in the treatment of breast, stomach and pancreatic cancer, remains the cornerstone of CRC treatment, although widely used in combination with several other drugs. Many effective drugs, including those actually used for cancer treatment, have been developed from botanical sources. Resveratrol is a pleiotropic phytochemical which is belong to the stilbene family. Although, it is only significantly present in grape products. Many preclinical studies investigated its anticancer properties in a plethora of cellular and animal models
Aim of the work: in the present study, the anticancer effects of Resveratrol alone or combined with 5-Fu were assessed on experimentally induced colorectal cancer in rats
Results: the results of this study indicated that RES had a better therapeutic effect against N-methylnitrosourea induced colorectal cancer than 5-Fu alone and when in combination with each other they diminished the cytotoxic effect of 5-Fu and enhanced normal histological appearance of colon tissue, which could be a promising alternative for resistant colorectal cancer. However, the exact mechanisms involved needs to be further explored
Conclusion: our results suggested that both natural compounds could be in the future a possible alternative to enhance the efficiency of 5-Fu in resistant colon cancer cells. This study supports the potential of plant extracts as source of bioactive compounds with biomedical applications
ABSTRACT
Two mosquito Species; Culex pipiens and Aedes caspius of different ages were experimentally infected with moderate microfilarial densities of Wuchereria bancrofti and examined for their vector potential to transmit this parasite. Tested age groups of Cx. pipiens supported the development of the infective stage of the parasite [L3] but those of Ae. caspius arrested its development especially aged mosquitoes. For Cx. pipiens, infection rates and the mean number of microfilaria [mf] were found decreased with insect age groups while their survival was not affected. Also, proportion of mosquitoes harbouring L3 of the parasite was quite similar for the examined age groups, however; the 4 days-old group was the highest. On the other hand, Ae. caspus capability to respond against W. bancrofti Was decreased in older mosquitoes. The observed results may indicate certain influence of mosquito aging on the development of W. bancrofti which differ according to mosquito species
Subject(s)
Wuchereria bancrofti/pathogenicity , Mosquito Control , Filariasis/prevention & controlABSTRACT
The melanization response of two mosquito against Wuchereria bancrofti was studied under different conditions of temperatures, adult age and feeding regimes. The two mosquito species were Culex pipiens, a susceptible species for W. bancrofti transmission and Aedes caspius a refractory one