ABSTRACT
Background: Reperfusion following ischemia can lead to more injuries than ischemia itself especially in diabetic patients. The aim of this study was to evaluate the effect of dexmedetomidine on ischemia-reperfusion injury [IRI] in rats with have hepatic IRI and diabetes mellitus
Methodology: Twenty-eight Wistar Albino rats were randomised into four groups as control [C], diabetic [DC], diabetic with hepatic ischemia-reperfusion injury [DIR], and diabetic but administered dexmedetomidine followed by hepatic IRI [DIRD] groups. Hepatic tissue samples were evaluated histopathologically by semiquantitative methods. Malondialdehyde [MDA], superoxide dismutase [SOD], glutathion s-transpherase [GST], and catalase [CAT] enzyme levels were investigated in liver and kidney tissues as oxidative state parameters
Results: In Group DIR; hepatocyte degeneration, sinusoidal dilatation, pycnotic nucleus, and necrotic cells were found to be more in rat hepatic tissue; while mononuclear cell infiltration was higher in the parenchyme. MDA levels were significantly lower; but SOD levels were significantly higher in Group DIRD with regard to Group DIR. In the IRI induced diabetic rats' hepatic and nephrotic tissues MDA levels, showing oxidative injury, were found to be lower. SOD levels, showing early antioxidant activity, were higher
Conclusion: The enzymatic findings of our study together with the hepatic histopathology indicate that dexmedetomidine has a potential role to decrease IRI?
ABSTRACT
Objective: The present study aims to evaluate intravenous ketamine and inhalation sedation in children, their unwanted side-effects and surgeon satisfaction
Methods:In this study, data of 922 children aged between 1-18 who underwent tooth extraction under sedoanalgesia in our department between September 2015-January 2016 were gathered and anesthesia approaches, unwanted side effects and surgical satisfaction was investigated. Postoperative recovery emergence agitation or delirium was evaluated with Watcha Behavior Scale [WBS]
Results:Patients were grouped and compared according to acceptance of intravenous line placement [Group-1] or not [Group- 2]. Group 1 received intravenous ketamine anesthesia [n=822], Group 2 received inhalation anesthesia with sevoflurane [n=100]. Number of patients, age, weight and gender was significantly different in two groups. When side effects were investigated nausea was observed in 30 patients [3.6%], skin rashes were observed in 26 patients [3.2%] in Group-1 while skin rashes were observed in one patient [1%] in Group 2. 95% of surgeons reported intravenous anesthesia, 18% of surgeons reported inhalation anesthesia to be the anesthesia of choice. Emergence of postoperative recovery agitation [WBS>/=3] was observed more frequent in Group 2 [p<0.05] than Group 1
Conclusion:Ketamine, which has analgesic, hypnotic and amnestic effects and which does not alter pharyngeal and laryngeal reflexes thus minimizes aspiration possibility, is a safe and effective anesthetic agent for tooth extractions of the pediatric population under sedoanalgesia
ABSTRACT
Objective: Unintentional dural puncture with an epidural needle is common and indisputably one of the most important complications of epidural anesthesia. When no regression of the complaints are observed after conservative treatment, epidural blood patch [EBP] should be planned for the treatment of patients. However, EBP is not the optimal choise because the success rate is low and the risk of potential serious complications is high. Ankaferd Blood Stopper® [ABS], which is a medicinal plant extract, has been used as a antihemorrhagic agent against various types of bleeding. The purpose of this study is to investigate the effects of ABS administration, on fibrin formation and cerebro-spinal fluid [CSF] leakage after dural puncture in a rat model
Methodology: The study was performed at Gazi University Experimental Research Center, Ankara, Turkey between May and July 2013. Eighteen rats were grouped randomly as control [Group C, n=6], dural punctured [Group DPC, n=6] and ABS application after dural puncture at the level of L4-L5 [Group A, n=6]. Methylene blue was applied to the cervical level of the rat spine, in order to observe leakage from dural puncture in Group DPC, and Group A. Medulla spinalis tissues of the rats were evaluated histopathologically
Results: CSF leakage was obtained in all rats in Group DPC [100%] that were dural punctured with spinal needle and given methylene blue. However, in the group of rats that ABS was performed before methylene blue [Group A] application, CSF leakage could be obtained in only half of the rats [50%], and in none of the rats in Group C. CSF leakage ratio in Group DPC was 100% and significantly higher than that in Group C [X[2]=5.178, p=0.002]. Following Ankaferd administration, CSF leakage was identified in only 50% of rats in group A and this result was similar with achieved result in Group C [X[2]=1.778, p=0.182]
Conclusion: We opine that Ankaferd Blood Stopper® [ABS] is effective in preventing CSF leakage after post dural puncture and does not cause necrosis in rat medulla spinalis tissues
ABSTRACT
To determine the effect of intraperitoneal [ip] nicotine on the recovery of rats receiving general anesthesia compared with placebo. The placebo controlled experimental study was conducted in the Faculty of Medicine, Gazi University, Turkey, between April and May 2005. Twenty-one male and 21 female rats were randomly divided into 3 groups. Group C [n=14], comprising a female group CF [n=7], and male group CM [n=7] received ip 0.9% sodium chloride [NaCl], group P [n=14], comprising a female group PF [n=7], and male group PM [n=7] received ip propofol 150 mg/kg, and group NP [n=14], comprising a female group NPF [n=7], and male group NPM [n=7] received 0.4 mg/kg ip nicotine followed by 150 mg/kg propofol after 15 minutes. For the evaluation of recovery period, tail pinch test was used, and for cognitive performance, the radial arm maze test was used. The number of entrances and exits decreased in group P significantly compared to group C [p<0.05], and the decrease in group PF was higher than it was in group PM. Entrance and exit in group NP increased significantly compared to group P [p<0.05]. The increase in entrance and exit in group NPF was much higher compared to group NPM. The recovery period in group NP was significantly shorter than in group P [p<0.05]. The ip administration of nicotine in rats shortens the recovery from propofol anesthesia and improves cognitive performance