ABSTRACT
Histopathology and various immunohistochemical markers were studied in 40 cases of human retinoblastoma. In histopathology, tumour type, extent and invasion were studied. In immunohistochemistry, both glial and neural markers were used to know the histogenesis of this tumour. The glial markers, glial fibrillary acidic protein and vimentin, were detected in retinal astrocytes and Muller's cells in normal retina and perivascular glia in retinoblastoma. The neural marker, neurone-specific enolase stained neurones in outer and inner nuclear layers in normal retina, Flexner-Wintersteiner rosettes in retinoblastoma and tumour cells is differentiated retinoblastoma. Another neural marker, neurofilament triplet polypeptide stained neurones in inner nuclear layer of normal retina and Flexner-Wintersteiner rosettes in well-differentiated retinoblastoma. These results support the view that retinoblastoma has predominantly neuronal origin.
Subject(s)
Child , Child, Preschool , Female , Glial Fibrillary Acidic Protein/immunology , Humans , Immunohistochemistry , Infant , Keratins/immunology , Male , Neurofilament Proteins/immunology , Neuroglia/pathology , Neurons/pathology , Phosphopyruvate Hydratase/immunology , Retinoblastoma/pathology , Biomarkers, Tumor , Vimentin/immunologyABSTRACT
Two unusual cases of Marcus Gunn phenomenon in adults are presented. The first case was characterised by a bilateral jaw-winking phenomenon along with an asymmetric bilateral congenital ptosis, whereas the second case had bizarre spontaneous movements of the affected lid, deficient abduction and pseudoptosis in association with jaw-winking. The pathogenesis of Marcus Gunn phenomenon is discussed.
Subject(s)
Adolescent , Blepharoptosis/physiopathology , Eyelids/physiopathology , Female , Humans , Jaw/physiopathology , MaleABSTRACT
A rare case of leiomyoma located anteroinferiorly in the orbit of a 39-year-old male patient is reported. The histopathogenesis and management is discussed.
Subject(s)
Adult , Humans , Leiomyoma/pathology , Male , Orbital Neoplasms/pathologyABSTRACT
A rare case of facio-orbital anamoly having dermolipoma with posterior extension, lid notch, ectropion, assymetric hypertelorism and lipoma of corpus callosum is presented. The classification of the facial cleft deformities and the surgical management is highlighted.
Subject(s)
Adult , Ectropion , Face/abnormalities , Female , Humans , Hypertelorism , Orbit/abnormalities , SyndromeABSTRACT
The results of split thickness autologous skin grafting along with the use of a dental impression material (Compo), a thermoplastic substance are presented in a series of 11 patients of acquired, severely contracted, anophthalmic sockets. Only the fornix fixation sutures and the central tarsorrhaphy were employed for the proper placement of graft without the use of retention devices. Artificial eyes were successfully fitted and retained subsequently after 6 weeks of grafting.
Subject(s)
Adolescent , Adult , Anophthalmos/pathology , Constriction, Pathologic , Dental Impression Materials/therapeutic use , Female , Humans , Male , Middle Aged , Orbit/pathology , Skin Transplantation , Suture TechniquesABSTRACT
A case of multiple wooden foreign bodies is presented. Any case presenting with a history of injury and a discharging sinus with osteomyelitis warrants a thorough exploration of the orbit. Anterior orbitotomy was performed and 4 pieces of arhar sticks were taken out. The guidelines for the management of the wooden foreign bodies are highlighted.