ABSTRACT
Introducción: El cáncer de mama es una enfermedad que va aumentando su incidencia anualmente; es así que en búsqueda de alternativas complementarias para el tratamiento, se han estudiado algunas plantas medicinales que contienen grandes cantidades de polifenoles, los cuales tienen efectos anticancerígenos como es el caso del Cenchrus echinatus L. Objetivo: Determinar la seguridad y el efecto protector del extracto etanólico de Cenchrus echinatus L. (cadillo) sobre el cáncer de mama inducido por 7,12-Dimetilbenzo[a]antraceno DMBA en ratas. Métodos: Estudio preclínico, experimental en ratones machos Balb/C53 y ratas Holtzman de ambos sexos. Se calculó la toxicidad aguda (DL50) y la toxicidad a 45 días mediante métodos de los probits y OECD respectivamente; para evaluar el efecto protector se utilizó el método de Barros 2004, también se registró microscópicamente la proliferación de células tumorales, utilizando el análisis estadístico descriptivo e inferencial, considerando p<0.05. Resultados: Los estudios de seguridad demuestran que el extracto no induce cambios significativos a nivel hematológico, bioquímico y anatomopatológico. Se logró un 76.92 % del efecto protector del extracto frente al cáncer de mama inducido por DMBA en ratas. Conclusiones: Se ha demostrado que el extracto de Cenchrus echinatus L. presenta efecto protector sobre el cáncer de mama inducido por 7,12-Dimetilbenzo[a]antraceno en ratas; y no es tóxico en ratones y ratas.
Introduction: Breast cancer is a disease that is increasing its incidence annually, so in search of complementary alternatives for treatment have been studied some medicinal plants containing large amounts of polyphenols, which have anticancer effects as is the case of Cenchrus echinatus L. Objective: To determine the safety and protective effect of ethanol extract of Cenchrus echinatus L. (burdock) on breast cancer induced by 7,12-dimethylbenz[a]anthracene in rats. Methods: Preclinical, experimental study in male Balb/C53 mice and Holtzman rats of both sexes. Acute toxicity and toxicity at 45 days were calculated using probit and OECD methods, respectively; to evaluate the protective effect, the Barros 2004 method was used; tumor cell proliferation was also registered microscopically, using descriptive and inferential statistical analysis, considering p<0.05. Results: Safety studies show that the extract does not induce significant hematologic, biochemical and pathological changes level 80% of the protective effect of the extract against DMBA-induced breast cancer in rats was achieved. Conclusions: It has been shown that Cenchrus echinatus extract L. has protective effect on breast cancer by 7,12-dimethylbenz[a]anthracene induced in rats; and it is not toxic in mice and rats.
ABSTRACT
Introducción: El embarazo es una etapa de cambios fisiológicos, psicológicos, personales y sociales para la mujer. El papel del aspecto emocional y psicológico abarca todo el periodo debido a que conforme avanza el desarrollo fetal, la relación madre-bebé se fortalece volviendo vulnerable a la madre. Objetivos: Recopilar, describir y analizar la información relevante sobre la salud mental en mujeres embarazadas, tanto en las diferentes etapas de la gestación como antes y durante la pandemia de COVID-19. Métodos: Se realizó una búsqueda de literatura por medio de PubMed, Google Scholar y Scielo por medio de terminología recopilada del MeSH y DeCs. Resultados: El embarazo debido a los cambios hormonales ocasiona la presencia de ansiedad y sentimientos de depresión que se agravan conforme avanzan las etapas de desarrollo fetal. Estos trastornos psicológicos han incrementado en gran medida durante la pandemia de COVID-19 debido a varias razones como la relación en pareja, la incertidumbre, miedo, angustia y fobia creciente por el contagio. Consideraciones finales: Las gestantes son una población vulnerable, la cual siempre ha visto afectada su salud mental y en la actualidad ha sido mucho más afectada debido a la pandemia, por ello necesitan de mejor atención en el sector de salud como brindarles información confiable sobre medidas para aliviar la carga de factores estresantes, ya que no solo cargan con la angustia de su salud sino también con la del feto.
Introduction: Pregnancy is a time of physiological, psychological, personal and social changes for women. The role of the emotional and psychological aspect encompasses the entire period because as fetal development advances, the mother-baby relationship strengthens, making the mother vulnerable. Objectives: To collect, describe and analyze relevant information on mental health in pregnant women, both at different stages of gestation and before and during the COVID-19 pandemic. Methods: A literature search was conducted through PubMed, Google Scholar and Scielo using terminology compiled from MeSH and DeCs. Results: Pregnancy due to hormonal changes causes the presence of anxiety and depression that worsen as the stages of fetal development progress. These psychological disorders have greatly increased during the COVID-19 pandemic due to several reasons such as the relationship with the couple, uncertainty, fear, anguish and increasing phobia about contagion. Final considerations: Pregnant women are a vulnerable population, whose mental health has always been affected and nowadays it has been much more affected due to the pandemic, therefore they need better attention in the health sector such as providing them with reliable information on measures to alleviate the burden of stressors, since they not only carry the anguish of their health but also that of the fetus.
ABSTRACT
The food frequency questionnaire (FFQ) is the preferred method to evaluate long-term usual dietary intake in population-based epidemiological studies because it is simple, easy to administer and requires minimal effort from the subjects. Therefore, we validated a food frequency interview schedule (FFIS) to estimate the dietary intakes of the urban population of Hyderabad city. Methods: A cross-sectional study was conducted among five socio-economic sections of Hyderabad. Areas for the survey were selected by cluster random sampling and households in each area were selected by simple random sampling. The FFIS was developed and validated against a 6-day 24-hour dietary recall (HDR) method. The instruments were administered to the participants six months apart to check for reproducibility. Statistical analyses for validation and reproducibility included correlation, regression analyses and paired t-test. Results: Means of intakes of foods measured by 24-HDR were significantly lower than those measured by FFIS for some foods at alpha levels of 0.05. Pearson's correlation (r) for the intakes by the two methods ranged from 0.12 to 0.85. Regression coefficients were significant for 12 food groups. Correlation coefficients for the two FFISs were between 0.31 (spices) and 0.81 (carbonated beverages) and showed good reproducibility. Intakes of conventional foods like cereals, pulses, vegetables etc. by FFIS correlated better with 24-HDR than the processed foods such as breakfast cereals and bakery items. Conclusion: The data suggests that the FFIS is a well-validated, reproducible tool for assessment of long term dietary habits of a specific population. However, its use for populations of other regions requires specific modifications.