Synthesis and spectral study of 1-(1-hydroxycyclohexane-1-yl)-n-substitutedthioamidoformamidinobenzyl

A novel synthesis of series of 1-(1-hydroxycyclohexane-1-yl)-Nsubstitutedthioamidoformamidinobenzyl (3a-e) was synthesized by the reaction of 1-(1- hydroxycyclohexane-1-yl) benzylcyanide (1) with various thiocarbamides (2a-e) and hydrochloric acid in acetone-ethanol (1:1) medium. Firstly the formation of products was justified on the basis of gas chromatography technique. Their separation was carried out by column chromatography. On these two chromatographical technique, reaction conditions were set for the isolation of pure products. The structure of all the synthesized compounds were justified on the basis of usual chemical characteristics, IR, and NMR spectral analysis respectively.