ABSTRACT
Purpose: To evaluate and compare the efficacy of autologous platelet?rich plasma (aPRP) eye drop and artificial tear (AT) eye drop in moderate to severe symptomatic dry eye disease (DED). Methods: This prospective interventional study included 121 eyes of 61 patients of moderate to severe DED. Patients were divided into aPRP (31 patients) and AT (30 patients) group. Ocular Surface Disease Index (OSDI) score, tear film breakup time (TBUT) (s), corneal fluorescein staining (CFS) score, and Schirmer test score (mm) of both the groups were evaluated and compared pre?treatment and post?treatment at the end of 3 months. Results: The mean age of the aPRP group and AT group was 52.8 ± 12.8 years and 55.5 ± 13.4 years, respectively. At the end of 3 months, OSDI score reduced more in the aPRP group as compared to AT group, and the mean difference (?22.7) was statistically significant (P < 0.001). There was no significant difference in post?treatment Schirmer test score between the two groups (P = 0.44). Post?treatment improvement in TBUT and CFS score in the aPRP group was significantly higher in the aPRP group as compared to that in the AT group (P < 0.05). Bruising at the site of blood withdrawal was noted in two patients in the aPRP group. Conclusion: aPRP is safe and more effective than AT in treating patients with moderate to severe symptomatic DED
ABSTRACT
Purpose: To study facial nerve palsy (FNP) in post?COVID?19?mucormycosis patients and its ocular complications, report different presentations of FNP in such patients, and propose its etiopathogenesis based on presentation and clinico?radiologic localization. Methods: A prospective cohort study was carried out in patients of post?COVID?19?mucormycosis who presented at our tertiary center, over a period of 3 months. Motor and sensory examination of the facial nerve was done to diagnose FNP and localize the lesion clinically. Slit?lamp examination was done for grading corneal involvement. MRI brain, orbit, and paranasal sinuses (PNS) with contrast were studied to find involvement along the facial nerve. It was assessed whether this site of lesion corresponded with clinical localization. Data were analyzed using the percentage of total cases and Fisher抯 test. Results: A total of 300 patients with post?COVID?19 mucormycosis were examined, of which 30 (10%) patients were found to have FNP. All were lower motor neuron (LMN) type and were associated with corneal complications. The most common site clinically was distal to the chorda tympani (66.66%) and radiologically was infratemporal (IT) fossa (63.4%). The clinical localization significantly correlated with the radiological findings (P = 0.012). Twenty percent of patients showed incomplete involvement of facial muscles. Conclusion: FNP was found to be of LMN type. The most common site of insult was IT fossa. There was a good clinico?radiological correspondence of lesions. Isolated lesions were also found along the peripheral nerve course, presenting as incomplete facial palsy. Recognition of FNP in post?COVID?19 mucormycosis, in all its variable forms, is important to manage corneal complications
ABSTRACT
To evaluate epidemiology of retinal and choroidal diseases and to calculate the Foveal Avascular Zone(FAZ), diameter and its variation with different diseases and analyse its impact on BCVA(Best corrected visual acuity) using Fundus fluorescein Angiography as diagnostic tool. Materials and methods: The study was conducted in 100cases of retinal and choroidalpathologies undergoing FFA Out of 100 patients maximum were in the age group 50-60 yrs with Diabetic Retinopathy as maximum incidence. FAZ in within normal eyes were in the range of 0.400mm-0.500mm while it increased in Diabetic retinopathy, BRVO,CRAO and hypertensive retinopathy. Eyes with larger FAZ had lower BCVA.