ABSTRACT
Background: Laparoscopic appendectomy is preferred because of increasing popularity and certain benefits over open method. Laparoscopic surgeries are conventionally done under general anaesthesia with positive pressure ventilation to avoid shoulder pain, respiratory embarrassment and abdominal discomfort caused by pneumoperitoneum. The data regarding use of spinal anaesthesia for laparoscopic appendectomy is limited. This study was designed to evaluate laparoscopic appendectomy under spinal anaesthesia along with the use of intravenous injection ketamine and intravenous injection dexmedetomidine. Objectives of this study were to observe efficacy of both drugs in reducing shoulder pain, need of rescue analgesia, need of conversion to open method due patient discomfort, changes in hemodynamic parameters, postoperative nausea and vomiting. Methods: After approval of ethical committee of institute , 100 patients of age group between 18-60 years with ASA grade I or II undergoing laparoscopic appendectomy with written informed consent were included in this study .All patients were informed about standard spinal anaesthesia technique in detail and also about the risk of conversion to general anaesthesia.Spinal anaesthesia procedure was carried out with hyperbaric injection bupivacaine 0.5% . Patients were randomized in two groups. One is Group K (n=50) patients who received injection Ketamine and other is Group D (n=50) patients who received injection Dexmedetomidine intravenously.Intraoperative hemodynamic parameters,shoulder pain,abdominal discomfort,need of rescue analgesia ,postoperative recovery were monitored and recorded. Results: No patients during study required conversion to general anaesthesia or open method. VDS(verbal descriptive scale) score for referred shoulder pain was statistically lower in group K compared to group D.Group D was associated with statistically significant lower heart rate and blood pressure than Group K. Conclusion:Injection ketamine and injection dexmedetomidine, both drugs are efficacious for reduction of referred shoulder pain with more hemodynamic stability in ketamine group during laparoscopic appendectomy.
ABSTRACT
Introduction: In therapeutic management of psychiatric illness the response to electroconvulsive therapy may be attenuated if anesthesia that is used abolishes or inhibits seizures. Anesthetic agents used for electroconvulsive therapy should provided smooth and rapid induction, a rapid recovery, minimal alteration of the physiological effects of electroconvulsive therapy as well as minimal antagonistic effects on seizure activity. Material and methods: In study of 120 patients with ASA grade I or II, having indication for Electroconvulsive therapy, half were randomly anaesthetized by 2.5% Thiopental Sodium with dose 3 mg/kg (Group I) and 1% Propofol in 1.5 mg/kg dose (Group II). A current of 110 volts was psychiatrist. Pulse and Blood pressure monitoring and Seizure response were evaluated along with side effects if any. Observation: After Induction, systolic BP in the 2 Groups did not show any significant (p>0.05) difference while the diastolic BP was significantly (p<0.05) lower in the propofol group. After suxamethonium systolic and diastolic BP were significantly (p<0.05) decreased in the propofol group. After completion of seizure systolic BP came down to basal level at 10 mins and diastolic BP came down to basal level at 15 mins. While in the thiopentone sodium group, the BP did not come down even the end of 15 mins. The duration of seizure activity in the propofol group was markedly reduced (p<0.05) as compared to the thiopentone sodium group. The time from induction to eye opening and induction to walking unaided were significantly (p<0.001) lower in the propofol groups suggesting faster recovery. During induction, higher percentage of patients showed discomfort on injection in the propofol group while during recovery headache, nausea and vomiting were noted in more patients within thiopentone group. Conclusion: Propofol group compared to thiopentone sodium had reduced increase in BP and pulse rate, reduced duration of seizure activity. Recovery was faster and side effects were reduced during recovery.