ABSTRACT
Introduction: Nail disorders comprise about 10% of alldermatological conditions. They may get involved invarious systemic diseases, infectious processes, nutritionaldeficiencies, ageing, genetic disorders, and neoplasms.Current study objective was to see the clinical pattern of nailchanges in patients presenting with various nail disorders andto determine the clinical pattern of nail involvement in variousdermatoses.Material and methods: This was a cross sectional study inwhich patients presenting to our department with any naildisorders were examined. A proper history, examination andthe relevant investigations like KOH, nail culture, and nailbiopsy were also done.Results: A total of 500 patients were screened, 282 femalesand 218 males. The most common nail change observed waslongitudinal ridging (45.6%), followed by distal subungualhyperkeratosis (35.8%) and cuticular changes (35.2%).Onychomycosis was the most common nail disorder observed,constituting 36.2% of all nails diseases. Among non infectivediseases, nail psoriasis was the most common nail disorderfollowed by nail lichen planus.Conclusion: A variety of nail changes can occur in variousdermatological and various other systemic disorders. So athorough clinical examination of nails is of prime importanceto correlate all these nail changes and to make dermatologiststo reach a conclusive diagnosis.
Subject(s)
Child , Female , Humans , Immunocompetence , India , Tuberculosis, Cutaneous/diagnosis , Tuberculosis, Cutaneous/drug therapy , Tuberculosis, Cutaneous/diagnostic imaging , Tuberculosis, Osteoarticular/diagnosis , Tuberculosis, Osteoarticular/drug therapy , Tuberculosis, Osteoarticular/diagnostic imagingABSTRACT
Ellis-van Creveld (EVC) syndrome is a rare autosomal recessive congenital disorder characterized by chondrodysplasia and polydactyly, ectodermal dysplasia and congenital defects of the heart. We present here a case of a 16-year-old short-limbed dwarf with skeletal deformities and bilateral postaxial polydactyly, dysplastic nails and teeth, also having left-sided facial hemiatrophy. The diagnosis of EVC syndrome was made on the basis of clinical and radiological features. To the best of our knowledge, this is the first report of EVC syndrome with facial hemiatrophy in the medical literature from India.
ABSTRACT
BACKGROUND: Alopecia areata (AA) is a recurrent, nonscarring type of hair loss considered to be an autoimmune process. Though its etiopathology is not fully understood, there are claims that imbalance of trace elements may trigger the onset of AA. AIM: The aim of the present study was to assess the levels of zinc, copper, and magnesium in the serum of AA patients. METHODS: Fifty AA patients (34 men and 16 women), and fifty age and sex matched healthy control subjects were studied. Samples were analyzed using atomic absorption spectrometric methods. RESULTS: Serum zinc levels were significantly decreased (P < 0.05) in AA patients whose disease was extensive, prolonged, and resistant to treatment, whereas serum copper and magnesium levels showed insignificant rise compared to controls. CONCLUSION: We conclude that copper and magnesium levels are not altered in AA, but the decreased zinc levels found in our study may merit further investigation of the relationship.