1.
Indian J Biochem Biophys
; 1989 Apr; 26(2): 109-19
Article
in English
| IMSEAR
| ID: sea-27951
ABSTRACT
The application of McGhee and von Hippel's general equation [J. Mol. Biol., 86 (1974), 469-489, Eq. (15)] to the analysis of the interaction of intercalative drugs with DNA has been further simplified. The value of n can now be determined mathematically, using a simple function, and without any approximation. It is also established that the summation of squared deviation of (( (nu/c), nu)) points would be minimum for and only for the true set of (K,n,omega) of the interaction system. The method incorporating the simplification has been applied to determine the binding parameters of adriamycin-DNA interaction according to the above general equation.
Subject(s)
Animals , Cattle , DNA/drug effects , Drug Interactions , Intercalating Agents/pharmacology , Mathematics
2.
Indian J Biochem Biophys
; 1986 Aug; 23(4): 197-203
Article
in English
| IMSEAR
| ID: sea-27348
3.
J Indian Med Assoc
; 1954 Oct; 24(1): 1-4
Article
in English
| IMSEAR
| ID: sea-101735
4.
J Indian Med Assoc
; 1953 Jul; 22(10): 393-6
Article
in English
| IMSEAR
| ID: sea-103186