ABSTRACT
Many plant substances are known for their interference with the central nervous system (CNS). Dioclea grandiflora Mart. Ex. Benth (Fabaceae) is a plant used in folk medicine to treat prostate disorders and kidney stones whose extracts from its seeds and root barks were reported to have a significant activity on the CNS and analgesic effect in rodents. In this study, the psychopharmacological activities of D. grandiflora were investigated, using the pods of this plant. Swiss mice were submitted to acute treatments with ethanol extract from the pods of D. grandiflora (EDgP) at doses of 75, 150 and 300 mg/kg by intraperitoneal administration followed by the evaluation of anxiety, depressant and anticonvulsant-related responses. The treatment with EDgP produced a depressant activity on the CNS and a sedative effect in mice. These findings suggest that EDgP has a central activity in mice, indicating an anxiogenic effect.
Varias sustancias de plantas son conocidas por su acción en el sistema nervioso central (SNC). La Dioclea grandiflora Mart. Ex. Benth (Fabaceae) es una planta utilizada en la medicina popular para tratar enfermedades en la próstata y piedras en los riñones, cuyos extractos de sus semillas y de las cáscaras de sus raíces presentan una actividad significativa sobre el SNC y efecto analgésico en roedores. En este estudio, las actividades psicofarmacológicas de D. grandiflora fueron investigadas, utilizando la vaina de la planta. Camudongos Swiss fueron sometidos a tratamientos agudos por la administración intraperitoneal del extracto etanólico de la vaina de D. grandiflora (EDgP) en dosis de 75, 150 y 300 mg/kg administrados intraperitonealmente seguida por la evaluación de respuestas relacionadas con la ansiedad, depresión y anticonvulsivo. El tratamiento con EDgP produjo una actividad depresora sobre el sistema nervioso central y un efecto sedante en camundongos. Estos resultados sugieren que EDgP tiene una actividad central en camundongos, indicando un efecto ansiogénico.
Subject(s)
Animals , Mice , Analgesics/pharmacology , Dioclea/chemistry , Plant Extracts/pharmacology , Hypnotics and Sedatives/pharmacology , Central Nervous System , EthanolABSTRACT
A detailed chemical analysis of the non-volatile secondary metabolites of Encyclia longifolia Schltr. syn. Epidendrum longifolium Barb. Rodr. was carried out in an attempt to lend a chemotaxonomic support for the recent separation of the genus Encyclia into Encyclia Hook and Prosthechea Knowles & Westc.
Uma análise química detalhada dos metabólitos secundários não voláteis de Encyclia longifolia Schltr. Sin. Epidendrum longifolium Barb. Rodr. foi realizada na tentativa de prestar suporte quimiotaxonômico para a recente separação do gênero Encyclia em Encyclia Hook e Prosthechea Knowles & Westc.
ABSTRACT
In our continued studies on the genus Solanum for detecting a good source of soladodine, the steroid alkaloid potentially important for the manufacture of steroid hormones, as well as other compounds of potential therapeutic value, we investigated the fruits of Solanum crinitum, S. rhytidoandrum, and S. jabrense belonging to the subgenus Leptostemonum and S. stipulaceum, belonging to the subgenus Brevantherum, allof which are native of the northeastern region of Brazil and yielded solasodine in moderate to high yield.
ABSTRACT
As part of a systematic investigation of the Ipomoea species of Northeastern Brazil, a mixture of 7,4'-diO-methylkaempferol and 7,3',4'-tri-Omethylquercetin were identified in extracts obtained from the aerial parts of Ipomoea horrida.
Como parte de uma investigação sistemática das espécies de Ipomoea do Nordeste do Brasil, foi identificado uma mistura de 7,4' -diO-methilkaempferol e ,3',4'-tri-Omethilquercetina isoladas das partes aéreas de Ipomoea horrida.