1.
Article
in English
| IMSEAR
| ID: sea-64551
ABSTRACT
Rodent model of filariasis was developed by infecting Wistar rats with Litomosoides carinii. Liver function tests, plasma protein concentrations, and synthesis rates of liver-formed proteins were estimated in these rats at 63 and 90 days post-infection. At 63 days post-infection, aspartate aminotransferase and alkaline phosphatase were significantly increased. Alanine aminotransferase, plasma total proteins and plasma albumin were in the normal range. However, at 90 days post-infection all these parameters were affected, reflecting progressive liver involvement. Hypoalbuminemia at 90 days post-infection did not appear to be due to decreased synthesis rate, indicating higher catabolism and/or altered distribution in pools.
Subject(s)
Animals , Arvicolinae , Blood Proteins/metabolism , Filariasis/physiopathology , Liver/physiopathology , Liver Diseases, Parasitic/physiopathology , Male , Rats , Rats, Inbred Strains
2.
Indian J Pathol Microbiol
;
1988 Jul; 31(3): 248-50
Article
in English
| IMSEAR
| ID: sea-74718