ABSTRACT
Background: Perinatal asphyxia is a significant cause of neonatal mortality and morbidity. MRI is useful for assessing the severity and pattern of brain injuries. There is less data of MRI findings of perinatal asphyxia from India and the subcontinents. This prospective observational study was done to describe MRI brain findings in neonates with perinatal asphyxia with respect to various determinants.Methods:' Initial MRI brain was done when babies were stable after fulfilling inclusion criteria. Immediate outcome was assessed at the end of hospital stay. They were followed up for presence of any sequel up to 1 year. Repeat MRI brain was done in few selected babies. Data was collected and statistically analyzed.Results: Total 55 babies were included in the study (term 27, preterm 28). There were 9 babies in stage 1, 17 babies in stage II and 22 babies in stage III. MRI brain findings were normal in 8 and abnormal in 47 patients. There were Deep gray matter injury (DG) in 22, Para Sagittal subcortical white matter injury (PS) in 6, Germinal matrix haemorrage (GMH), intraventricular haemorrage (IVH) and Periventricular leucomalacia (PVL) in 12 and Mixed pattern of injury in 7 babies. Findings among 9 expired babies were: 4 (44.4%) DG, 2 (22.2%) GMH+IVH and 3 (33.3%) mixed. There was neurological sequel in 13 babies (48.1%).' Babies with normal MRI initially had no sequel.Conclusion: Brain injury due to perinatal asphyxia follows several patterns according to gestational age and severity. Early and accurate recognition of these patterns with the help of MRI brain helps in managing the baby and predicting the prognosis.
ABSTRACT
Objective: To generate data of electrocardiogram (ECG) parameters according to gestationalage in Indian newborns. Methods: An observational study was carried out over 7 months inneonatology unit of a tertiary care teaching hospital. Following auscultation, ECG parameterswere recorded simultaneously in 12 leads, on third day of life, in hemodynamically stableneonates. Data from 364 babies were analyzed, keeping at least 30 records for eachgestational age between 30 to 42 weeks. Results: There was no difference in mean heart raterecorded through auscultation and ECG traces. The mean (SD) values recorded were: Pwave duration 0.04 (0.01) s, P wave amplitude 1.3 (0.4) mm, T wave duration 0.07 (0.02) s, Twave amplitude 1.1 (0.6) mm, PR interval 0.09 (0.02) s, QRS duration 0.04 (0.01) s, QTinterval 0.26 (0.02) s, QTc 0.4 (0.03) s and QRS axis 127 (22) degree. Gestation age-wisepercentile charts of different ECG parameters were generated. Conclusion: Thesegestational age-wise percentile charts of different ECG parameters for Indian newborns canbe used as reference for neonatal ECG
ABSTRACT
Systemic Lupus Erythematosus (SLE) may have different neurological manifestations. Mononerits multiplex is the most common type of peripheral nervous system involvement in adult population, but case reports in pediatric population are sparse. We are reporting a case of pediatric SLE, presenting with polyarthritis and subsequently developing mononeuritis multiplex, identified by NCV.