ABSTRACT
Objective: To identify the association between radiation dose volume and acute hematological toxicity [HT] in postoperative gynecological cancer patients receiving whole pelvic radiotherapy [RT] or intensitymodulated RT [IMRT], a principal component regression model was used to calculate HT
Methods: Women [n=100] receiving with or without chemotherapy RT were retrospectively analyzed, 52 of whom received chemotherapy [paclitaxel and nedaplatin]. The pelvis and lumbar vertebrae, defined as the prolong-pelvic bone marrow, were divided into the [1] combined ilium, ischium and pubis and the [2] lumbar vertebrae and the sacrum. The V5-V40 of subsides was calculated. The complete blood counts were recorded weekly. The principal component analysis was performed on volumes which generated the principal components [PCs], followed by using a logistic regression model
Results: Forty-seven patients presented with grade 2-3 HT during RT. Chemotherapy increased the incidence of HT compared with RT alone [70.21% vs. 29.79%; p=0.001]. Fifty-three patients with persistent HT developed more serious HT at an earlier stage of RT. The chemotherapy cycles and three PCs associated with grade 2-3 HT was identified to form the resulting principal logistic regression model
Conclusion: A new method to calculate the NTCP was achieved by PCs logistic regression