ABSTRACT
Objective:To investigate the effect of methylprednisolone sodium succinate combined with azithromycin in the treatment of severe mycoplasma pneumonia.Methods:From December 2015 to October 2017, a total of 85 children with severe mycoplasma pneumonia in the General Hospital of Gujiao Mining Area were divided into two groups according to the random number table method, 42 cases in the control group were treated with azithromycin, and 43 cases in the observation group were treated with azithromycin+ methylprednisolone sodium succinate.The clinical efficacy, disappearing time of symptoms and signs(fever, cough, pulmonary rales) and the level of serum C reactive protein(CRP) were compared between the two groups.The changes of serum levels of immunoglobulin M(IgM), IgA and IgG in two groups before and after treatment were also statistically analyzed.Results:The total effective rate of the observation group was 93.02%(40/43), which was higher than that of the control group [76.19%(32/42)] (χ 2=4.647, P=0.031). The disappearing time of fever, cough and pulmonary rales in the observation group were shorter than those in the control group( t1=4.787, P1=0.000, t2=5.746, P2=0.000, t3=6.418, P3=0.000). After treatment, the serum level of CRP in the observation group was lower than that in the control group( t=16.797, P=0.000). After treatment, the serum levels of IgM, IgA and IgG in the observation group were higher than those in the control group( t1=7.593, P1=0.000, t2=3.583, P2=0.001, t3=10.277, P3=0.000). Conclusion:Methylprednisolone sodium succinate combined with azithromycin can reduce the inflammatory reaction of children with severe mycoplasma pneumoniae, regulate their immunity and promote the recovery of symptoms and signs.Besides, its efficacy is obvious.
ABSTRACT
Objective@#To investigate the effect of methylprednisolone sodium succinate combined with azithromycin in the treatment of severe mycoplasma pneumonia.@*Methods@#From December 2015 to October 2017, a total of 85 children with severe mycoplasma pneumonia in the General Hospital of Gujiao Mining Area were divided into two groups according to the random number table method, 42 cases in the control group were treated with azithromycin, and 43 cases in the observation group were treated with azithromycin+ methylprednisolone sodium succinate.The clinical efficacy, disappearing time of symptoms and signs(fever, cough, pulmonary rales) and the level of serum C reactive protein(CRP) were compared between the two groups.The changes of serum levels of immunoglobulin M(IgM), IgA and IgG in two groups before and after treatment were also statistically analyzed.@*Results@#The total effective rate of the observation group was 93.02%(40/43), which was higher than that of the control group [76.19%(32/42)] (χ2=4.647, P=0.031). The disappearing time of fever, cough and pulmonary rales in the observation group were shorter than those in the control group(t1=4.787, P1=0.000, t2=5.746, P2=0.000, t3=6.418, P3=0.000). After treatment, the serum level of CRP in the observation group was lower than that in the control group(t=16.797, P=0.000). After treatment, the serum levels of IgM, IgA and IgG in the observation group were higher than those in the control group(t1=7.593, P1=0.000, t2=3.583, P2=0.001, t3=10.277, P3=0.000).@*Conclusion@#Methylprednisolone sodium succinate combined with azithromycin can reduce the inflammatory reaction of children with severe mycoplasma pneumoniae, regulate their immunity and promote the recovery of symptoms and signs.Besides, its efficacy is obvious.