ABSTRACT
Objective@#To analyze the correlation between the Spondyloarthritis Research Consortium of Canada (SPARCC) magnetic resonance imaging (MRI) sacroiliac joint inflammation score (SPARCC score)/structural score (SSS) and the disease activity as well as the functional indexs. The correlation between the MRI score and inflammatory indicators [erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)] in patients with active axial spondyloarthritis (axSpA) before and after treatment was explored. In addition, the contribution of the two MRI scoring method in evaluating conditions was also explored.@*Methods@#According to the inclusion criteria, 24 patients with active axial SpA were recruited and received the recombinant hauman tumor necrosis factor (TNF)-α receptor Ⅱ: IgG Fc fusion protein(rhTNFR:Fc), sulfasalazine and thalidomide for 12 weeks. Subjects were scored at week 0 and 12 by SPARCC/SSS scores. Bath ankylosing spondylitis disease activity index (BASDAI), Assessment of Spondyloarthritis Intemational Society (ASAS)-endorsed disease activity score(ASDAS)-CRP, bath ankylosing spondylitis functional index (BASFI). Bath ankylosing spondylitis metrology index(BASMI), ESR and CRP. The correlation between the SPARCC/SSS scores and that of clinical indicators were analyzed. Paired sample t test, Wilcoxon signedrank test, Spearman correlation analysis and Pearson correlation analysis were used for statistical analysis, and receiver operating characteristic curve (ROC) was used to evaluate the effectiveness of SPARCC score decline as a response to treatment.@*Results@#① Compared with baseline, after 12 weeks treatment, SPARCC scores [(15±4) and(33±10)], BASDAI [(3.2±0.9) and (5.2±1.1)], BASFI [(2.3±0.6) and (4.6±1.0)], BASMI [(2.3±0.7) and (4.1±1.1)], ASDAS-CRP scores [(2.0±0.8) and (3.7±0.9)], ESR [(16±12) mm/1 h and (49±26) mm/1 h], CRP [(7.2±2.8) mg/L and (30.4±19.3) mg/L] were significantly decreased (t values were 7.822, 6.950, 10.707, 7.204, 6.281,-4.015 and-4.257, respectively), and the differences were statistically significant (P=0.000). There was no significant difference in SSS scores between baseline [(20±6) and (19±7)] and after 12 weeks treatment (t=-0.761, P=0.455). ② Before treatment, SPARCC score showed positive linear correlation with BASDAI (r=0.630, P=0.001), ASDAS-CRP (r=0.646, P=0.001), CRP (r=0.574, P=0.003) and ESR (r=0.559, P=0.004), and the correlation of the above indexes disappeared after treatment (P>0.05). The association between SPARCC structral scores and the above indicators was not significant before and after treatment. ③ Areas under curve(AUC) of ROC for assessing treatment response by reduced SPARCC scores was 0.809. The cut-off value for response to treatment was 20.5, with the sensitivity of 68.8% and specificity of 75.0%.@*Conclusion@#The SPARCC MRI SIJ inflamm-ation score has certain value in evaluating disease activity and efficacy, while the SPARCC SSS is not.
ABSTRACT
Objective To analyze the correlation between the Spondyloarthritis Research Consortium of Canada (SPARCC) magnetic resonance imaging (MRI) sacroiliac joint inflammation score (SPARCC score)/structural score (SSS) and the disease activity as well as the functional indexs.The correlation between the MRI score and inflammatory indicators [erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)] in patients with active axial spotdyloarthritis (axSpA) before and after treatment was explored.In addition,the contribution of the two MRI scoring method in evaluating conditions was also explored.Methods According to the inclusion criteria,24 patients with active axial SpA were recruited and received the recombinant hauman tumor necrosis factor (TNF)-α receptor Ⅱ:IgG Fc fusion protein (rhTNFR:Fc),sulfasalazine and thalidomide for 12 weeks.Subjects were scored at week 0 and 12 by SPARCC/SSS scores.Bath ankylosing spondylitis disease activity index (BASDAI),Assessment of Spondyloarthritis Intemational Society (ASAS)-endorsed disease activity score (ASDAS)-CRP,bath ankylosing spondylitis functional index (BASFI).Bath ankylosing spondylitis metrology index (BASMI),ESR and CRP.The correlation between the SPARCC/SSS scores and that of clinical indicators were analyzed.Paired sample t test,Wilcoxon signedrank test,Spearman correlation analysis and Pearson correlation analysis were used for statistical analysis,and receiver operating characteristic curve (ROC) was used to evaluate the effectiveness of SPARCC score decline as a response to treatment.Results ① Compared with baseline,after 12 weeks treatment,SPARCC scores [(15±4) and (33±10)],BASDAI [(3.2±0.9) and (5.2±1.1)],BASFI [(2.3±0.6) and (4.6±1.0)],BASMI [(2.3±0.7) and (4.1±1.1)],ASDAS-CRP scores [(2.0±0.8) and (3.7±0.9)],ESR [(16±12) mm/1 h and (49±26) mm/1 h],CRP [(7.2t2.8) mg/Land (30.4±19.3) mg/L] were significantly decreased (t values were 7.822,6.950,10.707,7.204,6.281,-4.015 and-4.257,respectively),and the differences were statistically significant (P=0.000).There was no significant difference in SSS scores between baseline [(20±6) and (19±7)] and after 12 weeks treatment (t=-0.761,P=0.455).② Before treatment,SPARCC score showed positive linear correlation with BASDAI (r=0.630,P=0.001),ASDAS-CRP (r=0.646,P=0.001),CRP (r=0.574,P=0.003) and ESR (r=0.559,P=0.004),and the correlation of the above indexes disappeared after treatment (P＞0.05).The association between SPARCC structral scores and the above indicators was not significant before and after treatment.③ Areas under curve(AUC) of ROC for assessing treatment response by reduced SPARCC scores was 0.809.The cut-off value for response to treatment was 20.5,with the sensitivity of 68.8％ and specificity of 75.0％.Conclusion The SPARCC MRI SIJ inflammation score has certain value in evaluating disease activity and efficacy,while the SPARCC SSS is not.
ABSTRACT
Objective To survey the prevalence of Hyperuricemia (HUA) in elder population of Changchun city,and to detect the correlation between cardiovascular risk factors and the HUA.Methods 900 residents older than 55 years were selected randomly for this questionnaire survey.Physical and laboratory examinations were performed.Results The HUA prevalence rate elder people in Xixin District of Changchun was 16.0％(144/900),while the rates were 13.7％(50/365),15.2％(47/309) and 20.8％(47/226) (P＜0.05) in the elder group (55-65 years),the aged group (66-75 years),and the advanced aged group (older than 76 years) respectively;there was no statistical significant difference in the prevalences between male and female (x2=0.023 5,P＞0.05).The HUA prevalence rate was significantly different between people who had different level of blood pressure,cholesterol,hypersensitive C-reactive protein (hs-CRP),body mass index (BMI),waisthip ratio (WHR).The level of uric acid (UA),total cholesterol (TC) and hs-CRP was significantly different in people with high uric acid when compared with those of normal patients (P＜0.05).There was positive correlation between UA level and TC,triglyceride (TG) level (r=0.364,P＜0.05;r=0.479,P＜0.05).Conclusion The HUA prevalence rate increases significantly as people getting older.There is positive correlation between the increase of uric acid level and the major cardiovascular risk factor.People with hypertension,hyperlipidemia,overweight and obese have high risk for HUA,so change life style and dietary habits may prevent or reduce the occurrence of HUA.