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Objective To evaluate the therapeutic effectiveness and toxicity of low-dose cisplatin chemotherapy combined with three-dimensional conformal radiotherapy for mid-advanced esophageal cancer.Methods 89 patients with advanced esophageal cancer either who were inoperable or refused operation were randomized into two groups: 45 cases in the study group and 44 cases in the compared group. The study group
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Objective To compare and observe the effect and side effect of two different kinds of simulation mode for nasopharyngeal carcinoma conventional radiotherapy. Methods 147 cases were randomly divided into the study group (74 cases, CT simulation) and the control group (73 cases, X-ray radiography simulation). In the study group three-dimensional treatment planning system (IPS) was used to draw target volume and organ at risk, and then beam eye view (BEV) function was utilized to design treatment plan and subsequent plan modulation. In the control group X-ray simulation radiography was used. Two groups of plan design and subsequent plan modulation mode were exactly the same, and the radiotherapy were performed on the same accelerator. Results For these two groups, there were 5-59 months follow-up. The recent therapeutic effect of nasopharyngeal carcinoma primary site and cervical lymph node metastasis was regular,and no statistical significance (P >0.05). For the study group 3-year local recurrence rate was 5.4 % (4/74) while the control group was 16.4 %(12/73), and there was obvious statistical significance between two groups. About one year and three year accumulated survival rate, the study group was 98.5 %, 77.4 %, and for the control group was 92.9 %, 64.7 %. Two groups survival curves were examined by Log-rank test: the survival curves showed statistical significance between two groups(P <0.05). In control group, stage II and III radiotheray reaction of oralis mucosa was significantly increased compared with that of the study group (P < 0.05). There were two cases radioactivity cerebral palsy and one case optic nerve damage in the control group, but no serious dermatosis, soft tissue fibrosis and radioactivity posterior cranial nerve damage. Conclusion The CT simulation which is applied to nasopharyngeal carcinoma conventional radiotheraphy could improve therapeutic effect and reduce cancer recurrence and radiation side effect.
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Objective To observe the radioprotective effect of low dose mitomycin C(MMC) on chest carcinoma. Methods 100 cases of chest carcinomas confirmed by histologic or cytologic diagnosis, including, esophageal carcinoma 54 cases, lung cancer 46 cases, were randomized into study group and control group, 50 cases in each group. The study group was treated with low dose MMC (0.002 mg/kg iv one time per week, about 5 ~ 7 times in the course) during routine radiotherapy, the control group was treated with routine radiotherapy only. Results All of 100 cases completed the treatment. Acute radiation- induced esophagitis of study group and control group was 30 % and 48 % respectively (?2=3.897,P =0.048). Acute radiation- induced pneumonia of study group and control group was 4 % and 16 % respectively (?2 =4.001,P =0.045). Hematologic toxicity of study group and control group was 50 % and 48 % respectively (?2=0.208, P =0.648). Response rate of study group (84 %) was obviously higher than that of control group (68 %) (?2 =4.089, P =0.043). Conclusions Low dose MMC combining with chest carcinoma's radiotherapy can obviously reduce acute radiation- induced esophagitis and pneumonia, without obvious hematologic toxicity, meanwhile increase radiation effect.
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0.05). The corresponding 1-, 2- and 3-year loca l r ecurrence rates were 4.4%, 8.9%, 13.3% and 9.8%, 26.8%, 32.6% (P 0.05). Conclusions Simultaneous small-field boosting radiotherapy can obviously reduce t he local recurrence and improve the survival without causing more toxicities in the treatment of soft tissue sarcoma in extremities.