bcl-2 and bad protein expression in breast carcinoma / 中国普通外科杂志

Objective To determine gene bcl 2 and bad protein expression in tissues of breast cancer and precancerous lesions, its relation with estrogen receptor (ER) and progesterone receptor(PR), and lymph node metastasis.Methods Using immunohistochemical method, the expression of bcl 2 and bad gene were observed in 8 cases of normal breast tissues, 19 cases of simple breast hyperplasia, 20 cases of breast atypical hyperplasia and 48 cases of breast cancer. Results bcl 2 expression was positive in all normal breast tissues and simple hyperplasia, compared to 58 33% in breast cancer and 85 0% in atypical hyperplasia(all P

Effect of esophageal variceal ligation on portal hypertensive gastropathy / 中国微创外科杂志

Objective To investigate the effect of esophageal variceal ligation (EVL) on portal hypertensive gastropathy (PHG). Methods Gastroscopic examinations were performed both before and after the EVL in 37 cases of PHG. Results The severity of PHG was correlated with the liver functions, and the morbidity of PHG was higher in cases of Child C (100%, 9/9) than in cases of Child A (60%, 12/20) or Child B (80%, 16/20) ( ? 2=18 452,P =0 001). PHG could be exasperated by the application of EVL, but no statistical significance was seen ( ? 2=3 512,P =0 173). On re-examination of gastroscopy 6~12 months later, no relapse or re-bleeding of esophageal varices or gastric mucosa hemorrhage occurred. Conclusions The worse the liver functions, the higher is the incidence of PHG. EVL treatment creates a tendency to aggravating PHG.

Differentiating diagnosis of no nipple discharge disease by fiberoptic ductoscopy / 中国普通外科杂志

Objective To study the characteristics of breast disease and the effect of differentating diagnosis of breast disease under fiberoptic ductoscopy(FDS). Methods 50 cases of breast disease were examined by FDS. Results There were hyperplasia of mammary glands in 31 cases; chronic mastitis in 5 cases; ductal ectasia in 7 cases and breast cancer in 7 cases by FDS in this series. The accord rate of pathological diagnosis with FDS was 98%,and with clinical diagnosis was 76%.Conclusions FDS is a very important and new method in the diagnosis of breast disease .FDS can detect early breast cancer. It can be used as intervening treatment for some intraductal papilloma and chronic inflammatory disesase.FDS has precis location and qualitation effect for diagnosis of breast disease. FDS will greatly influence the diagnosis and treatment of breast cancer.