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Objective To understand the current situation of iodine deficiency disorders of Xinjiang Production and Construction Corps,in order to provide evidence for establishing prevention and control strategies.Methods According to their sub-area positions of east,west,south,north and center,5 units were extracted in each division via the random sampling method,4 companies were sampled in each chosen unit,15 households were selected in each chosen company to detect salt iodine content in 2015;and 1 elementary school was sampled in each chosen unit,40 students aged 8-10 were selected to collect their urine samples in each school to test urinary iodine and determine the goiter.Twenty pregnant women were randomly selected in each unit to test urinary iodine.Salt iodine was tested using direct titration,urinary iodine was determined using arsenic osmium catalytic spectrophotometry,thyroid was examinated using B-ultrasound.Results Totally 3 915 edible salt samples were monitored.The mean of salt iodine was (27.8 ± 5.5) mg/kg,with 99.1％ (3 880/3 915) iodized salt coverage rate,93.2％ (3 617/3 880) iodized salt qualified rate and 92.4％ (3 617/3 915) qualified iodized salt consumption rate.The goiter rate was 1.0％ (26/2 552) and the median of urinary iodine was 217.9 μg/L of 2 552 children aged 8-10,urinary iodine of southern region and northern region was 212.1 and 222.1 μg/L,respectively.The median of urinary iodine of 1 233 pregnant women was 157.7 μg/L.Conclusion The iodine nutrition level of key groups have already reached the national standard for eliminating iodine deficiency disorders,we should pay more attention to lower level urinary iodine of pregnant women.
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Objective To determine the effects of different excipients ( amino acids, carbohydrates and nonionic surfactants) on thermal stability of the IgG1 monoclonal antibody, and to examine the interactions between the excipients and the protein.Methods Differential scanning calorimetry ( DSC) was used to study thermal stability of the protein in different solutions and got information on the solubility of the unfolded forms of the protein.Isothermal titration calorimetry ( ITC) was used to examine the binding interactions between the excipients and the protein.ResuIts Negatively charged amino acids could significantly reduce the denaturation temperature (Tm) of IgG1( Tm >9 ℃), and other excipients didn’t have a major effect ( Tm <1℃).Excipients shared different impacts on thermal stability of the IgG1 monoclonal antibody under different pH, and negatively charged amino acids result in a much lower Tm at pH 5 than at pH 7.The ITC binding isotherms of different excipients (including polysorbate 20 and 80) and IgG1 were almost straight lines, while there was strong binding interaction between polysorbate 20 or 80 and Human Serum Albumin (HSA).ConcIusion The results suggest that there is no binding interaction between these studied excipients and the IgG1 monoclonal antibody; instead electrostatic interactions seem to play a leading role between the excipients and the IgG1 monoclonal antibody.
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OBJECTIVE@#To assess and compare the two procedures, total thyroidectomy (TT) and partial thyroidectomy (PT), for papillary thyroid cancer in terms of associated injuries, postoperative complication, recurrence rate and survival, so as to provide a reference and basis for surgical procedure option of this disease.@*METHOD@#Strictly specified into the exclusion criteria, the combination of computer retrieval and manual retrieval and retrieval systems such as CNKI, Wang Fan, PubMed, central, CBM database. Total thyroidectomy and partial thyroidectomy for the treatment of patients with thyroid papillary cancer related literature were compared, with the retrieval time until December 31, 2013.@*RESULT@#According to the retrieval strategy 4630 literatures were found, and 20 witch matched the exclusion criteria were left, all were retrospective study. TT and PT group of recurrent laryngeal nerve injury rate are 5.9%, 2.0% respectively [OR = 0.39, 95% CI (0.17 - 0.90), P < 0.05], TT and PT group of parathyroid injury rate are respectively 4.9%, 0.8% respectively [OR = 0.23, 95% CI (0.08 - 0.68), P < 0.01]. The TT group of 10 years survival rate is 95.24% - 100%, and the PT group is 96.8% - 99.2% [OR = 0.03, 95% CI (0 - 0.34), P < 0.01]. Unstaged, unstaged TT group' postoperative recurrence rate is 4.7%, while PT group is 12.6% [OR = 3.21, 95% CI (1.57 - 6.57), P < 0. 01]. Postoperative recurrence of stage I TT group and PT group are 4.9%, 7.8% respectively [OR = 3.82, 95% CI (1. 07-13.66) P < 0.05]; The rate of stage II TT group is 0.5%, while the rate of PT group is 15.9% [OR = 17.23, 95% CI (4.03 - 73.73), P < 0.01].@*CONCLUSION@#Different methods of primary thyroid papillary carcinoma surgical treatment can all obtaina good survival, but the rate of laryngeal recurrent nerve injury and parathyroid injury caused by partal throidectomy is relatively lower. As a result, partial thyroidectomy can be a good choice for early stage thyroid papillary carcinoma.