ABSTRACT
Background: currently different criteria are used to diagnose Gestational Diabetes. ACOG [American college of obstetric and Gynecology] accepted NDDG's [criteria National Diabetes Data Group] Criteria and ADA [American Diabetes Association] accepted Carpenter Caustan's. Although both of these criteria have been achieved by O Salivan and Mahan's reaserches, the number of patients has been diagnosed are different .The aim of this study was to compare Gestational Diabetes prevalence according to Carpenter Caustan's and NDDG's Criteria
Methods: 1200 pregnant women were screened in a prenatal care clinic. Patients with definite diabetes were excluded. According to universal GDM screening method, for all of the patients GCT and GTT [if GCT > 130] were preformed. The results evaluated according to Carpenter Caustan's and NDDG's criteria
Results: in this screening, 377 participants had positive GCT, according to Carpenter and Caustan's criteria 83 women [6.9%], and according to NDDG criteria 50 women [3.6%] had Gestational Diabetes Mellitus. If the cut of point of GCT was 140 mg/dl instead of 130 mg/dl, according to Carpenter and Caustan's criteria 16 women [18.1%], and according to NDDG 4 patients [9%] were missed
Conclusion: regarding the significant difference between two methods in diagnosis of gestational diabetes mellitus, assessment of each method value in improving prognosis and outcomes is necessary. According to the results the cut of point of 130mg/dl, as recommended in previous studies, has more accuracy for screening
ABSTRACT
Background: previous clinical and experimental studies suggest the valuable effect of antioxidants on lipids status. The present study was designed to investigate the efficacy of silymarin treatment as an antioxidants on lipids profile in type II diabetic hyperlipidemic patients
Methods: a 4-month randomized double blind clinical trial was conducted in 54 non-insulin dependent diabetic hyperlipidemic patients in a two well - matched groups. First group [n=29] received 200mg silymarin tablet 3 times a day plus standard therapy, while the control group [n=25] received placebo tablet 3 times a day plus standard therapy. The patients were visited monthly and fasting blood glucose, total cholesterol, LDL, HDL cholesterol, triglyceride, SGOT and SGPT were determined at the beginning and at the end of the study after four months
Results: results revealed that in silymarin treated patients, fasting blood glucose, LDL and total cholesterol, triglycerid, SGOT, SGPT and glucose level at the end of the study were significantly decreased as compared to beginning of the study. In placebo treated patients fasting blood glucose level at the end of the study were significantly increased as compared to beginning of the study
Conclusion: in conclusion, the silymarin as an herbal antioxidant have beneficial effects on reducing glucose and lipids profile in type II diabetic patients