ABSTRACT
With the rapid progress of exploration of basic and clinical gastroenterology, the understanding of gut-brain axis, interaction of metabolism-neuroimmunity-intestinal microecology leading to gastrointestinal inflammation and regulatory mechanism of enteric nervous system had significantly changed the recognition of definition, clinical manifestation, diagnosis and management of gastroparesis. In this article, the implications of these changes for the clinical practice of gastroparesis were reviewed and prospected.
ABSTRACT
Dysphagia increases the risks of mortality and palindromia post stroke, and influences the rehabilitation and quality of life. All the patients with stroke need a set of clinical screening, and those positive would accept comprehensive evaluation, both bedside and lab-oratory. Many approaches have been used for dysphagic rehabilitation, but it is not clear what the best is.
ABSTRACT
Objective To investigate the transfer rate of alkaloids in extraction and purification process of Cortex Phellodendri Amurensis (CPA) and to ascertain the optimal purification technology.Methods We purified the alkaloids from Cortex Phellodendri Amurensis by AB-8 macroporous resin.With the contents of berberine hydrochloride and palmatine hydrochloride as the reference indexes,content determination of alcohol extract,sample solution and eluent from AB-8 macroporous resin were determined by HPLC.Results The optimal technology was as follows:using 8-fold 75 %(V/V) ethanol as extract,extracting for 3 times and lasting one hour for each time.The transfer rate of alkaloids was 83.75 %under the above condition.The transfer rate of alkaloids was about 80 %when the concentration of sample solution(pH value being 8 and centrifugation) was 0.1 g/mL,and the transfer rate of alkaloids in eluent was 75.14 %.Conclusion The optimum technology is stable and feasible,and the purification effect of alkaloids from Cortex Phellodendri Amurensis by AB-8 macroporus resin is good.