ABSTRACT
OBJECTIVE To study the distribution and drug-resistance status of pathogens in surgically infective specimen in Renmin Hospital of Qichun County and provide the reference for clinically reasonable use of antibiotics.METHODS The infective specimen were collected to perform bacterial culture.The routine methods were adopted to identify pathogenic bacterium.Susceptibility testing was performed by K-B method.RESULTS Among 322 strains from surgically infective specimen,Staphylococcus aureus,Escherichia coli and Pseudomonas aeruginosa,ranking the top three,accounted for 25.2%,15.8% and 13.0%,respectively.The detection rate of meticillin-resistant S.aureus(MRSA) was 32.1%.And that of meticillin-resistant coagulase negative Staphylococcus(MRCNS) was 33.3%.That of extended spectrum ?-lactamases(ESBLs) producer in E.coli and Klebsiella pneumoniae was 34.5%.Various pathogenic bacterium had been resistant to antibiotics to different extents.100.0% of Gram-positive cocci were sensitive to vancomycin.The sensitivity rate to imipenem in Gram-negative bacilli was 19.0-100.0%.CONCLUSIONS Drug resistance variesd from pathogenic bacterium in surgical infection.The clinician should reasonably choose antibiotics according to results of bacterial culture to avoid occurrence and prevalence of drug-resistance bacterium.