ABSTRACT
Two new steroidal alkaloids, isoconkuressine and N-formylconessimine, together with 6 known steroidal alkaloids including conkuressine, conessine, isoconessimine, conimine, conarrhimine, and funtudienine, were isolated from the seeds of Holarrhena antidysenteriaca Wall.ex A.DC. Their intrinsic antibacterial activities and synergistic effects with penicillin and vancomycin were analyzed in methicillin sensitive staphylococcus aureus (MSSA) and methicillin resistant staphylococcus aureus (MRSA). Two of the steroidal alkaloids including one new compound (N-formylconessimine) showed potential antibacterial activity and possessed synergistic effects with penicillin and vancomycin, respectively.
Subject(s)
Alkaloids , Pharmacology , Anti-Bacterial Agents , Chemistry , Pharmacology , Holarrhena , Chemistry , Methicillin-Resistant Staphylococcus aureus , Microbial Sensitivity Tests , Plant Extracts , Chemistry , Pharmacology , Staphylococcus aureusABSTRACT
<p><b>OBJECTIVE</b>To study the chemical constituents of Caesalpinia minax.</p><p><b>METHOD</b>The chemical constituent was isolated by various chromatographic metheds and its structure was elucidated by the analysis of spectral data and physiochemical properties.</p><p><b>RESULT</b>One diterpenoid compound was isolated from the 95% ethanolic extract of C. minax, and identified as 12alpha -methoxyl-14beta-hydroxy-lalpha, 6alpha, 7beta-triacetoxycass-13 (15)-en-16, 12-olide.</p><p><b>CONCLUSION</b>Neocaesalpin L1 was a new compound and named as neocaesalpin L1.</p>