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Chondroprotective potential of root extracts of Withania somnifera in osteoarthritis.

Sumantran, Venil N; Kulkarni, Asavari; Boddul, Sanjay; Chinchwade, Trushna; Koppikar, Soumya J; Harsulkar, Abhay; Patwardhan, Bhushan; Chopra, Arvind; Wagh, Ulhas V.

J Biosci ; 2007 Mar; 32(2): 299-307

Article in English | IMSEAR | ID: sea-111036

ABSTRACT

This is the first report describing two novel chondroprotective activities of aqueous extracts of Withania somnifera root powder.First,these extracts had a statistically significant,short-term chondroprotective effect on damaged human osteoarthritic cartilage matrix in 50% of the patients tested. Second,these extracts caused a significant and reproducible inhibition of the gelatinase activity of collagenase type 2 enzyme in vitro.

Subject(s)

Aged , Extracellular Matrix Proteins/metabolism , Glycoproteins/metabolism , Humans , Matrix Metalloproteinase 8/metabolism , Middle Aged , Osteoarthritis/drug therapy , Phytotherapy/methods , Plant Extracts/pharmacology , Plant Roots/chemistry , Proteoglycans/metabolism , Spectrophotometry , Time Factors , Withania/chemistry

ABSTRACT

Subject(s)

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