ABSTRACT
Interleukin 5 (IL-5) is a critical cytokine for the maturation of eosinophil precursors to eosinophils in the bone marrow and those eosinophils then accumulate in the lungs during asthma. We have studied anti-bodies on allergic responses in mice, guinea pigs anf monkeys and are extending this experiment into humans with a humanized antibody. In a monkey model of pulmonary inflammation and airway hyperreactivity, we found that the TRFK-5 antibody blocked both responses for three months following a single dose of 0.3 mg/kg i.v. This antibody also blocked lung eosinophilia in mice by inhibiting release from the bone marrow. To facilitate multiple dosing and to reduce immunogenicity in humans, we prepared Sch 55700, humanized antibody against IL-5. Sch 55700 was also active against lung eosinophilia in allergic monkeys and mice and against pulmonary eosinophilia and airway hyperresponsiveness in guinea pigs. Furthermore, as opposed to steroids, Sch 55700 dis not cause immunosuppression in guinea pigs. Studies with antibody in humans will be critical to establishing the therapeutic potential of IL-5 inhibition.
Subject(s)
Animals , Guinea Pigs , Humans , Mice , Antibodies , Interleukin-5/immunology , Lung/physiopathology , Asthma/immunology , Eosinophils , Haplorhini/immunology , Bronchial Hyperreactivity/physiopathology , Respiratory HypersensitivityABSTRACT
El hipotiroidismo aumenta su frecuencia con la edad. Las formas asintómaticas podrían ser detectadas mediante las determinaciones de Thyroid Stimulating Hormone (TSH) bajo el Test de THR (Thyroid Releasing Hormone) en los primeros estadios. La incidencia del hipotiroidismo subclínico (SCH) en la etapa del cimaterio no es bien conocida. El objetivo de este trabajo es realizar mediante la determinación de TSH, un "Screening" del Hipotiroidismo Subclínico (SCH) En 209 pacientes se determinaron valores de TSH, T3, T4 y anticuerpos antitiroideos y además se realizó ultrasonografía tiroidea