Effect of Iron and Its Chelators on Vibrio vulnificus Septicemia Experimentally Induced in Mice / 대한피부과학회지

Infection with V. vulnificus resulting in septicemia accompanied with skin gangrene and high mortality of 50% or more freqently occurs in people with liver disenses. And it has also been demonstrated that serum iron, essential to the growth of microorganisms, has been elevated in liver damaged animals. In spite of many efforts to reveal the pathogenesis of this fatal disease, there is no clear conclusion so far. Significant increase or decrease in LD of V. vulnificus (CDC C7184) was observed when mice were treated with ferric arnmonium citrate (FAC) and a specific iron chelator, desferal(Df), originated from Streptomyces pilosus and a broad spectrurn cation chelator, calciurn disodium ethylenediaminetetraacetate (CaEDTA) widly used in heavy metal poisoning treated alone or in combination. The results were obtained as follows. FAC and Df lowered LD to approximately 1.96x 10(3) colony forming unit (CFU) and 9.77x10(2) CFU respectively from 4.46 x 10(5) CFU, LDso of the control group. However, CaEDTA elevated the I D to 4.97 X 10(7) CFU. The LD of the group administered FAC and Df simultaneously was about 9.28x10(1) CFU. Whereas, the LD of the group administered FAC and CaEDTA simultaneously was approximately 7.88 x 10(5), similar to that of the control group. This study demonstrates that there is a close association of the iron with V. vulnificus septicemia and Df lowers LD of the rnice. CaED7A, however, elevated the LD. The author hereby proposes carefully iron chelators such as CaEDTA as an agent for a new adjuvant therapy of the V. vulnificus septicernia.

Clinical and Entomological Studies of Paederus Dermatitis / 대한피부과학회지

Paederus dermstitis (or dermatitis linearis), caused by the insect genus Paederus, is characterized by linear erythernatous, vesicopustular lesions. In 1968, we proved that causative agent is Paederus fuscipes. During the 20-year period since then (from June 1968 to September 1988), we have experienced 156 cases of the diseaes in our clinic, and the clinical features were studied with the following results. (1) They were found only during summer months from June to September. Most prevalent in June(47%), followed by August, July and September, in decreasing order. (2) People in their twenties were affected most often(10%), with females outnumbering males, by approximately 2.8 to 1. (3) The lesions were found exclusively over exposed areas, such as face, neck, and extremities (4) Experiments on a volunteer revealed that the same skin lesions as in the patients can be produced by rubbing the anal portion of the insect. (5) Spongiosis and subcorneal pustule of epidermis were the main histopathological findings. (6) The insects appear ant-like and measures 6.5 to 7mm in length. It has a black, round head with pslpuli black, rectangular, short elytra, yellowish brown pronotum and abdomen composed of 6 segments, of which two caudal ones(hypopygium) were dark brown. The meso and metathorax, and the lower ends of the femurs in meso and metapedes appear dark brown. (7) Wide use of potent pesticides, herbicides, or insecticides as well as the urbanization may have reduced the out breaks of the disease in recent years.

Clinical and Epidemiological Studies of Cysticercosis / 대한피부과학회지

Taenia aolium is responsible for producing human intestinal infection with the tapeworm (taeniasis) and the lodging of the larval stage (Cysticercua cellulosae) in numerous organs. especially subcutaneous tissue with the prodution

A Case of Omphalith / 대한피부과학회지

Omphalith generally consists of keratinous materials and sebum. It gradually forms a stone-like hard, dark brown to a black mass in elderly persons with deep umbilical depression and not clean umbilicus. A 75 years old male noticed a brownish black nodule on the umbilical depression 2 weeks ago. He did not try to remove it. This nodule gradually became to project from umbilical depression accompanied with intermittent pain. Removed specimen was brownish black stonelike on projecting polypoid lesion, but in umbilical depression, yellowish brown and not so hard. Histopathological examination showed a small quantity of melanin granules, but no nuclear components of cells.

Haemorrhagic Gangrene of Skin Caused by Aeromonas hydrophila

Aeromonas hydrophila is a motile gram negative rod which exists in soil and water. It can cause septicemia in persons with severe immune deficiency. Occasionally it is one of the etiologic agents of the gangrenous skin disease similar to the gangrene caused by Vibrio vulnificus septicemia. A 42-year-old farmer had been suffering from liver cirrhosis for about 3 years. He had episodes of melena and hematernesis for 2 days prior to coming to the emergency room but had no skin lesions. On the 2nd hospital day, painful, erythematous and edematous skin lesions developed on his left arm and on the 3rd hospital day, several purpuras and hemorrhagic bullae developed on his left arm and leg. In the tissue, blood and blister fluid, numerous gram negative rods were identified by direct smear and culture. The bacterial identification studies from blood and blister fluid revealed A. hydrephda.

A Case of Benign Neonatal Eruptive Hemangiomatosis / 대한피부과학회지

Benign neonatal eruptive hemangiomatosis is extremely rare congenital multiple hemangiomatic disease without systemic visceral involvement. The akin lesions are usually detected at birth and virtually disappear by the age of 12 months. A female infant of 27 days had three or four flat reddish purple maculopapules on the face from the time of birth. They spreaded into the entire body surface and increased in size forming plaque upto little finger tip size for 3 days. There was no evidence of asociated symptomatic visceral involvement. Histologically they were compatible with capillary angiomatous nevi. They began to resolve into residual hyperpigmented macules necrotizing centrally at 2 months of age and almo. completely resolved at 6 months of age without any treatment.