ABSTRACT
So far known Andrographis paniculata Nees (AP) is a hepatoprotective, antiplatelet and antithrombotic drug. In this experiment its hypoglycaemic effect has been tried in various way. Water extract of AP 10 mg/kg body weight can prevent induction of hyperglycaemia significantly (P < 0.001) induced by oral administration of glucose 2 mg/kg body weight. But any how failed to do so in adrenaline induced hyperglycaemia. It also failed to demonstrate any "fasting blood sugar lowering effect" upon chronic administration (6 weeks) of AP. So probably AP prevents glucose absorption from gut. Whole experiment was done on rabbits.
Subject(s)
Animals , Anticoagulants/pharmacology , Blood Glucose/analysis , Female , Hypoglycemia/chemically induced , Male , Plants, Medicinal , Platelet Aggregation Inhibitors/pharmacology , RabbitsABSTRACT
Ocimum sanctum is well known medicinal herb, highly available around the Indo-Pak Subcontinent and widely been used in many aliments. Its antimicrobial, antitusstive, hypolycaemic and hypochoglestrolaemic properties are familiar. In this study its hypoglycaemic property has been further explored and effect on pancreas was examined histologically. A total of 47 diabetic rats were treated in different groups with Ocimum sanctum, chlorpropamide and in combination for 15 days. Then the weight of the pancreas was measured and found significant increase in chlorpropamide treated group and in combined group. Beta cells increased significantly in Ocimum sanctum treated group and in combined treated group. Alpha cells reduced significantly [p <0.05] in combined group only. This experiment suggests the proliferation of B cells per islet