Testicular cancer patterns in Tunisian men: diagnosis problems, pathlogical types and prognosis. About 41 patients

To analyze the testicular cancer [TCa] incidence, diagnosis aspects, pathologic grade, stage, and survival in Tunisian men. we studied all patients who had histopathologically confirmed TCa treated in La Rabta University-Hospital between 1991 and 2010. Baseline demographic data included age at diagnosis, year of diagnosis, clinical symptoms, stage at diagnosis, histologic type, management strategies and survival were analyzed. The incidence of TCa among Tunisians in very low; we collected only 41 cases over a period of 20 years with an average incidence of 2 new cases per year. Peak age incidence was 30-49 years. testicular swelling was the principal complaint in 25 patients. 58.5% of tumours were right-sided and 39% were left-sided. There was bilateral involvement in only one case. The mean interval between onset of symptoms and presentation was 16.5 months [1-120]. Most patients presented at stages T2 and T3 [63.4% and 26.8% respectively]. Treatment consisted of radical orchidectomy in all patients and cisplatin-based chemotherapy and radiotherapy in respectively 11 and 12 patients [association in 5 patients]. One patient with a tumour in an intra-abdominal testis underwent laparotomy. The most common histological types were seminomas [n=20] and mixed germ cell [n=8]. Three patients died within 48 months, while half were lost to follow-up. The incidence of TCas in Tunisia remains low. Late presentation and treatment are major challenges to management. Better health funding and education regarding testicular self-examination is essential

[Lymphadenopathic form of alveolar rhabdomyosarcoma. A case report]

We report the case of a special form of rhabdomyosarcoma called "Iymphadenopathic" which was reported only two times in the literature. This lymphadenopathic alveolar RMS shows lymph nodes as clinical manifestation mimicking lymphoma with an unknown primary neoplasm. In the case we report, clinical examination, and radiological studies revealed superficial and deep located lymph nodes in association with bilateral pleural effusion. Conventional histological examination showed lymph node infiltration by a metastatic tumour having alveolar pattern. Some of tumour cells were round with multilobed off-centred nucleus and eosinophilic cytoplasm containing fibril material with longitudinal and transverse striation indicating a muscle nature of the tumour proliferation. The immunohistochemical study showed intense and diffuse immunoreactivity of tumour cells for vimentin and a discreet immunostaining by desmin. These findings were compatible with the diagnosis of lymph node metastasis by alveolar rhabdomyosarcoma